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Archive for the ‘Terpenoids’ Category

Crotophorbolone synthesis

Posted by naturalproductman on October 23, 2015

Masayuki Inouye and co-workers have reported in ACIE on the synthesis of crotophorbolone.

radical

ACIE paper

Posted in Cascade Reactions, Methodology, Radical Chemistry, Seven-Membered Rings, Terpenoids, Total Synthesis | Leave a Comment »

Asperchalasine A

Posted by naturalproductman on September 3, 2015

Here’s a natural product isolation paper that was published in ACIE. Yonghui Zhang and co-workers report on the isolation of asperchalasine A, which induced G-1 phase cell cycle arrest by reducing the expression of cyclin A, CDK2, and CDK6 in cancer cells but not in normal cells at 20 micromolar (pretty high concentration so not so potent in my opinion).

asperchalasine A

ACIE paper

Posted in Cancer, Chemical Biology, Dimer, Terpenoids | Leave a Comment »

trans-Clerodane natural product synthesis

Posted by naturalproductman on January 17, 2015

Larry Overman and co-workers have reported in JACS on the synthesis of trans-clerodane natural products.

clerodane

JACS paper

Posted in Asymmetric, Methodology, Terpenoids, Total Synthesis | 1 Comment »

Maoecrystal V synthesis

Posted by naturalproductman on December 15, 2014

Regan Thomson and co-workers at Northwestern have reported in JACS on a synthesis of maoecrystal V.

maoecrystal

JACS paper

Posted in Methodology, Terpenoids, Total Synthesis | Leave a Comment »

Taiwaniadducts B, C, and D syntheses

Posted by naturalproductman on June 3, 2014

Ang Li and co-workers from SIOC have reported in JACS on the syntheses of taiwaniadducts B, C, and D.

taiwaniadducts

JACS paper

Posted in Europium, Lanthanides, Methodology, Terpenes, Terpenoids, Total Synthesis | Leave a Comment »

Ingenol synthesis

Posted by naturalproductman on April 18, 2014

Phil Baran and co-workers reported in JACS on their synthesis of ingenol.

ingenol

JACS paper

Posted in Terpenoids, Total Synthesis | Leave a Comment »

Crotogoudin synthesis

Posted by naturalproductman on August 30, 2013

Erick Carreira and colleague have reported in ACIE on the synthesis of crotogoudin.

crotogoudin

ACIE paper

Posted in Methodology, Terpenoids, Total Synthesis | Leave a Comment »

Asperterpenoid A

Posted by naturalproductman on January 31, 2013

Zhigang She and co-workers from Sun-Yat Sen University have reported in Organic Letters on the isolation of asperterpenoid A, which had an IC50 value of 2.2 micromolar against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB).

ABCDE

OL paper

Posted in Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Terpenoids | Leave a Comment »

Amphilectene synthesis

Posted by naturalproductman on November 16, 2012

Ryan Shenvi and colleague at Scripps have reported in JACS on the synthesis of amphilectene, an antimalarial compound.

amphilectene

JACS paper

Posted in Diseases, Malaria, Terpenoids, Total Synthesis | Leave a Comment »

Indium bromide cyclization

Posted by naturalproductman on October 2, 2012

Teck-Peng Loh and co-workers from the University of Science and Technology have reported in ACIE on the synthesis of moluccanic acid methyl ester through a Prins-polyene cyclization using indium (III) bromide.

cascade

ACIE paper

Posted in Cascade Reactions, Methodology, Named Reactions, Prins, Terpenoids, Total Synthesis | Leave a Comment »

 
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