Naturalproductman’s Blog

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Archive for the ‘Tetrahydrofuran’ Category


Posted by naturalproductman on September 18, 2011

Karsten Krohn and co-workers at the University of Paderborn have reported in European JOC on the isolation of some biologically active tetrahydrofurans.


European JOC paper


Posted in Antibiotics, Tetrahydrofuran | Leave a Comment »

Orthodiffenes A-D

Posted by naturalproductman on December 7, 2010

Biswanath Das and co-workers at IICT have published in Tetrahedron Letters on the isolation of orthodiffenes A-D. Orthodiffene A had an IC50 value of 3.66 micrograms/mL against HL-60 cell lines.



TL paper

Posted in Tetrahydrofuran, Tetrahydropyran | Leave a Comment »

Osmium Catalyzed Oxidative Cyclization

Posted by naturalproductman on September 7, 2010

Timothy Donohoe and co-workers at the University of Oxford have published in Synlett on an osmium catalyzed oxidative cyclization of a vinyl silane tethered with an alcohol to form substituted tetrahydrofurans.

oxidative cyclization

Synlett paper

Posted in Cascade Reactions, Methodology, Osmium, Tetrahydrofuran, Transition Metal | Leave a Comment »


Posted by naturalproductman on April 28, 2010

Yu-Dong Zhou and co-workers from the University of Mississippi have recently reported in the Journal of Natural Products on the isolation of some tetrahydrofuran containing compounds 10-hydroxyglaucanetin, annonacin, and annonacin A, which inhibited hypoxia-induced HIF-1 activation at IC50 values of 12 nM, 13 nM, and 31 nM.

paw paw crude extract

JNP paper

Posted in Acetogenins, Tetrahydrofuran | 1 Comment »