Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Thiazoles’ Category

Mycothiazole synthesis

Posted by naturalproductman on August 21, 2015

Karl Hale and colleague at the Queen’s University Belfast have reported in Organic Letters on the synthesis of mycothiazole.

mycothiazole

OL paper

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Posted in Alkaloids, Methodology, Structural Reassignment, Thiazoles, Total Synthesis | Leave a Comment »

Plantazolicin A synthesis

Posted by naturalproductman on November 28, 2014

Steven Ley and co-workers at the University of Cambridge have reported in ACIE on the syntheses of plantazolicins A and B.

thiazole

ACIE paper

Posted in Methodology, Oxazoles, Thiazoles, Total Synthesis | Leave a Comment »

Forazoline A

Posted by naturalproductman on September 10, 2014

I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).

ACIE paper

Posted in Antifungal, New Setups, New Types, NMR, Polyketides, Polythio Compounds, Thiazoles | Leave a Comment »