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Archive for the ‘Total Synthesis’ Category

Regioselective acylation

Posted by naturalproductman on August 28, 2015

Takeo Kawabata and co-workers from Kyoto University have reported in ACIE on the synthesis of multifidosides through a regioselective acylation.

acylation

ACIE paper

Posted in Glycosides, Methodology, Regioselective, Total Synthesis | Leave a Comment »

Leucoridine synthesis

Posted by naturalproductman on August 28, 2015

Rodrigo Andrade and co-workers from Temple University have reported in ACIE on the synthesis of

Diels-Alder

ACIE paper

Posted in Alkaloids, Diels-Alder, Dimer, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Fijiolide A synthesis

Posted by naturalproductman on August 27, 2015

Nicolai Cramer and colleague from EPFL have reported in JACS on the synthesis of fijiolide A.

fijiolide

JACS paper

Posted in Aromatic, Macrolides, Total Synthesis | Leave a Comment »

Luteoalbusin synthesis

Posted by naturalproductman on August 27, 2015

Mohammad Movassaghi and co-workers have reported in Organic Letters on the syntheses of luteoalbusin.
polythio

OL paper

Posted in Alkaloids, Polythio Compounds, Total Synthesis | Leave a Comment »

Spiruchostatin A synthesis

Posted by naturalproductman on August 26, 2015

Takuyuki Doi and co-workers from Tohoku University have reported in Tetrahedron on a solid phase synthesis of spiruchostatin A.
spiruchostatin
Tetrahedron paper

Posted in Peptides, Total Synthesis | Leave a Comment »

Bicyclomycin formal synthesis

Posted by naturalproductman on August 26, 2015

Ullrich Jahn and co-workers from the Academy of the Sciences of the Czech Republic reported in ACIE on a formal synthesis of bicyclomycin.
radical
ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Diels-Alder approach to galbulimima alkaloids

Posted by naturalproductman on August 25, 2015

Here’s a paper related to the galbulimima alkaloids, which were made famous by Lewis Mander’s group. Regan Thomson and co-workers report in JACS on the synthesis of galbulimima alkaloids. A nice collaboration with DFT calculations from Dean Tantillo’s group shows the orbital interactions in the transition state structures of the Diels-Alder reactions.
galbulimima

JACS paper

Posted in Alkaloids, DFT, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

Mycothiazole synthesis

Posted by naturalproductman on August 21, 2015

Karl Hale and colleague at the Queen’s University Belfast have reported in Organic Letters on the synthesis of mycothiazole.

mycothiazole

OL paper

Posted in Alkaloids, Methodology, Structural Reassignment, Thiazoles, Total Synthesis | Leave a Comment »

Secu’amamine A synthesis

Posted by naturalproductman on August 21, 2015

Amos Smith and colleague have reported in Organic Letters on the synthesis of secu’amamine A.
secu'amamine A
OL paper

Posted in Alkaloids, Methodology, Multi-Component Coupling, Total Synthesis | Leave a Comment »

Griseusin synthesis

Posted by naturalproductman on August 20, 2015

Jon Thorson and co-workers from the University of Kentucky have reported in ACIE on the syntheses of griseusins.
griseusins
ACIE paper

Posted in C-H activation, Methodology, Polyketides, Total Synthesis | Leave a Comment »

 
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