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Archive for the ‘Total Synthesis’ Category

Debromohamigeran E synthesis

Posted by naturalproductman on July 3, 2015

James Morken and colleague at Boston College have reported in JACS on the synthesis of debromohamigeran E.
boron
JACS paper

Posted in cross coupling, Methodology, Total Synthesis | Leave a Comment »

Shishijimicin A synthesis

Posted by naturalproductman on July 3, 2015

Nicolaou and co-workers at Rice University have reported in JACS on the synthesis of shishijimicin.
shishijimicin A
 

JACS paper

Posted in Total Synthesis | Leave a Comment »

Dragmacidin D synthesis

Posted by naturalproductman on July 1, 2015

I first was introduced to dragmacidins when I started reading work about Stoltz’s group, which was published in JACS, but I didn’t know that Zakarian’s group has also been working on its synthesis and published it in ACIE.

dragmacidin

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Trichodermamides A, B, and C syntheses

Posted by naturalproductman on June 30, 2015

Oleg Larionov and co-workers at UT San Antonio have reported in JACS on the syntheses of trichodermamides A, B, and C.

polyketide

JACS paper

Posted in Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Limonin synthesis

Posted by naturalproductman on June 7, 2015

Masahiro Hirama and co-workers at Tohoku University have reported in ACIE on the synthesis of limonin.

limonin

ACIE paper

Posted in Total Synthesis | Leave a Comment »

Spirooliganone synthesis

Posted by naturalproductman on June 6, 2015

Shishan Yu and co-workers from the Chinese Academy of Sciences at have reported in Organic Letters on the synthesis of spirooliganone, which had 0.41 μM IC50 activity against Coxsackie virus B3.

spirooliganone
OL paper

Posted in Antiviral, Polyketides, Total Synthesis | Leave a Comment »

Alzmaphorazine B synthesis

Posted by naturalproductman on June 6, 2015

Christopher Vanderwal and colleague have reported in JACS on a synthesis of alzmaphorazine B.

alkaloid

JACS paper

Posted in Alkaloids, Biosynthesis, Total Synthesis | Leave a Comment »

Nodulisporic acid D synthesis

Posted by naturalproductman on June 6, 2015

Amos Smith and co-workers have reported in JACS on the synthesis of nodulisporic acid D.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis, Transition Metal | Leave a Comment »

Synthesis of Paclitaxel exploiting new ways

Posted by naturalproductman on May 28, 2015

Noritaka Chida and co-workers from Keio University have reported in Organic Letters on a radical cyclization approach toward taxol.

taxol

OL paper

They access the oxetane ring via intramolecular mesylate displacement.

OL paper2

Posted in Cascade Reactions, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Brevisin via epoxide ring opening

Posted by naturalproductman on May 28, 2015

Timothy Jamison and co-workers have reported in JACS on their formal synthesis of brevisin.

polyepoxide

JACS paper

Posted in Cascade Reactions, Formal Synthesis, Rhodium, Total Synthesis, Transition Metal | Leave a Comment »

 
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