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Archive for the ‘Total Synthesis’ Category

Naupliolide A synthesis

Posted by naturalproductman on February 12, 2016

Hisanaka Ito and co-workers at Tokyo University of Pharmacy and Life Sciences have reported in ACIE on the synthesis of naupliolide A.

 

ACIE paper

Posted in Sesquiterpenes, Total Synthesis | Leave a Comment »

Gracilamine formal synthesis

Posted by naturalproductman on February 12, 2016

Scott Snyder and co-workers at the University of Chicago have reported in ACIE on a formal synthesis of gracilamine.

Snyder ACIE 2016.gif

ACIE paper

Posted in Alkaloids, Diels-Alder, Named Reactions, retro-Diels-Alder, Total Synthesis | Leave a Comment »

Hippolachnin A synthesis

Posted by naturalproductman on February 12, 2016

Kevin Brown (Indiana University) and John Wood (Baylor University) and co-workers have reported in JACS on the synthesis of hippolachnin A.

 

JACS paper

Posted in Polyketides, Total Synthesis | Leave a Comment »

Strictamine synthesis

Posted by naturalproductman on February 4, 2016

Jieping Zhu and co-workers reported in ACIE on the synthesis of strictamine.

 

ACIE paper

Posted in Indoles, Total Synthesis | Leave a Comment »

A review of total synthesis and prospects for the future

Posted by naturalproductman on February 3, 2016

Larry Overman and co-workers have reported in ACIE on a nice review of 12 elegant examples of total synthesis of natural products bearing 2 or more quaternary carbon centers bonded to each other. I like that it is a nice “cliff notes” version of a lot of great work.

 

ACIE paper

Posted in Random, Total Synthesis | Leave a Comment »

Laurenidificin synthesis

Posted by naturalproductman on February 3, 2016

Shoji Kobayashi and co-workers from Osaka Institute of Technology have reported in JOC on the synthesis of laurenidificin.

 

JOC paper

Posted in Tetrahydrofuran, Total Synthesis | Leave a Comment »

Grandilodine C synthesis

Posted by naturalproductman on February 2, 2016

Atsushi Nishida and co-workers from Chiba University have reported in ACIE on the synthesis of grandilodine C.

 

ACIE paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

Tubulysin syntheses

Posted by naturalproductman on February 2, 2016

KC Nicolaou and co-workers have reported in JACS on the synthesis of tubulysin and some analogs. There are some interesting propellane analogs that reminded me of the recent Baran paper in Science that involved some strain-release amination reactions – the Baran paper involved the use of strained rings that would react with free amines to form new C-N bonds. I like the analogy in this photograph, where the two co-first authors of the paper (holding hands) represent the “strained ring” and the “amine” is Phil Baran pouring a flask to break the strain.

JACS paper

One pot C-N bond formation (Science paper):

RING STRAIN RELEASE 02.02.2016.gif

Posted in Methodology, Strained Rings, Total Synthesis | Leave a Comment »

Jungermannenones B and C synthesis

Posted by naturalproductman on January 29, 2016

Xiaoguang Lei and co-workers from Peking University have reported in ACIE on the synthesis of jungermannenones B and C.

 

ACIE paper

Posted in Cascade Reactions, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Fusarisetin A synthesis

Posted by naturalproductman on January 27, 2016

Yandong Zhang and co-workers at Xiamen University have reported in Organic Letters on a synthesis of fusarisetin A using a one pot intramolecular Diels-Alder/Mukaiyama aldol reaction cascade sequence.

OL paper

Posted in Cascade Reactions, Diels-Alder, Named Reactions, One pot, Total Synthesis | Leave a Comment »

 
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