Naturalproductman’s Blog

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Archive for the ‘Total Synthesis’ Category

Towards halichondrins

Posted by naturalproductman on May 12, 2015

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

halichondrin

JACS paper

JACS paper 2

Posted in Chromium, cross coupling, Methodology, Named Reactions, Nickel, Polyketides, Total Synthesis | Leave a Comment »

HIV integrase inhibitor synthesis

Posted by naturalproductman on May 12, 2015

Chris Senanayake and co-workers from Boehringer-Ingelheim have reported in ACIE on the synthesis of

HIV

ACIE paper

Posted in Diseases, HIV, Total Synthesis | Leave a Comment »

Sarain A synthesis

Posted by naturalproductman on May 12, 2015

Tohru Fukuyama and co-workers at Nagoya University and the University of Tokyo have reported in ACIE on a formal synthesis of sarain A.

sarain

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Muironolide A synthesis

Posted by naturalproductman on May 4, 2015

Armen Zakarian and co-workers have reported in JACS on the synthesis of muironolide A.

muironolide A

JACS paper

Posted in Macrolides, Structural Reassignment, Total Synthesis | Leave a Comment »

Gelsemoxonine synthesis

Posted by naturalproductman on May 4, 2015

Erick Carreira and colleague have reported in JACS on the synthesis of gelsemoxonine.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Serpentine synthesis

Posted by naturalproductman on May 2, 2015

Karl Scheidt and co-workers have reported in ACIE on the synthesis of alstonine and serpentine through cooperative catalysis.
heteroyohimbine
ACIE paper

Posted in Alkaloids, Cooperative Catalysis, Methodology, Total Synthesis | Leave a Comment »

Mycoleptodiscin A synthesis

Posted by naturalproductman on April 26, 2015

Ang Li and co-workers from SIOC have reported in ACIE on the synthesis of mycoleptodiscin A.

mycoleptodiscin
ACIE paper

Posted in Alkaloids, Steroids, Total Synthesis | Leave a Comment »

Eudistidine A

Posted by naturalproductman on April 20, 2015

The NCI does some nice work with natural products. Kirk Gustafson and co-workers at Bethesda have reported in JACS on some new natural products that block the interaction between p300 and HIF1alpha.

70

JACS paper

Posted in Alkaloids, Protein-Protein Interaction, Proteins, Total Synthesis | Leave a Comment »

Steenkrotin A synthesis

Posted by naturalproductman on April 18, 2015

Huanfeng Ding and co-workers from Zhejiang University have reported in ACIE on the synthesis of steenkrotin A.

steenkrotin A

ACIE paper

Posted in Diterpenoids, Methodology, Radical Chemistry, Total Synthesis | Leave a Comment »

Ouabagenin synthesis

Posted by naturalproductman on April 17, 2015

Masayuki Inoue and co-workers from the University of Tokyo have reported in Chemical Science on the synthesis of ouabagenin.

 
ouabagenin
Chemical Science paper

Posted in Steroids, Total Synthesis | Leave a Comment »

 
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