Larry Overman and co-workers reported in JACS on the synthesis of chromodorolide B.
Archive for the ‘Triterpenoids’ Category
Posted by naturalproductman on February 24, 2016
Posted by naturalproductman on September 11, 2015
Dionicio Siegel and co-workers at UCSD have reported in JACS on the synthesis of celstrol.
Posted by naturalproductman on March 7, 2014
Bernd Plietker and co-workers at Universitat Stuttgart reported in JACS on the synthesis of guttiferone A.
Posted by naturalproductman on May 5, 2012
Hongbin Zhai and co-workers at the Chinese Academy of Sciences have published in ACIE on the synthesis of merrilactone where they used a Pauson-Khand reaction as one of the key steps.
Posted by naturalproductman on August 10, 2011
Thomas Simmet and co-workers from Ulm University have reported in the Journal of Natural Products on the isolation of (8R)-3β,8-Dihydroxypolypoda-13E,17E,21-triene from the oleogum resin of P. lentiscus. This compound had inhibitory activity against androgen-insensitive prostate cancers (~10 micromolar).
Posted by naturalproductman on May 25, 2011
Keiji Tanino and co-workers from Hokkaido University have reported in Nature Chemistry on the synthesis of solanoeclepin A – this molecule is similar to glycinoeclepin in activity and structure…the biological activity is related to dafachronic acid where it stimulates the hatching of nematodes.
Posted by naturalproductman on May 6, 2011
Jiangong Shi and co-workers at the Chinese Academy of Medical Sciences have reported in Organic Letters on the isolation of machilusides.
Posted by naturalproductman on November 22, 2010
Pascal Wafo and co-workers from France have published in Organic Letters on the isolation of duboscic acid. It had alpha-glucosidase inhibition activity with with an IC50 value of 100 ± 8.1 μM. So you might wonder why alpha-glucosidase inhibition is important – alpha-glucosidase is an enzyme that hydrolyzes disaccharides into monosaccharides so the inhibition of this enzyme should slow down the absorption of glucose in people, which is especially important in diabetic patients.
Posted by naturalproductman on September 24, 2010
Toshihiro Nohara and co-workers at Sojo University have published in the Journal of Natural Products on the isolation of a compound that may help prevent atherosclerosis by inhibiting acyl-CoA:cholesterol acyl transferase (ACAT) or “CE” accumulation (cholesterol ester accumulation) at high doses (~50 micromolar – 40% CE accumulation inhibition). Although the compound, esculeogenin A, was not as effective as the synthetic compound CI976, which inhibited CE accumulation by 90% at 5 micromolar, it was important to point out that the compound is from a natural food source.
Posted by naturalproductman on August 10, 2010
Orazio Taglialatela-Scafali and co-workers from Universita di Napoli “Federico II” in Italy have published in the Journal of Natural Products on the isolation of two triterpenoids dubbed neemfruitins A and B that had antiplasmodial activities of 1.74 and 9.98 micromolar IC50 values against the W2 strain of Plasmodium falciporum.