Naturalproductman’s Blog

Hey, is that a natural product?!

Luteoalbusin synthesis

Posted by naturalproductman on August 27, 2015

Mohammad Movassaghi and co-workers have reported in Organic Letters on the syntheses of luteoalbusin.
polythio

OL paper

Posted in Alkaloids, Polythio Compounds, Total Synthesis | Leave a Comment »

Spiruchostatin A synthesis

Posted by naturalproductman on August 26, 2015

Takuyuki Doi and co-workers from Tohoku University have reported in Tetrahedron on a solid phase synthesis of spiruchostatin A.
spiruchostatin
Tetrahedron paper

Posted in Peptides, Total Synthesis | Leave a Comment »

Vinyl chlorides from terminal alkynes

Posted by naturalproductman on August 26, 2015

Silvie Derien and co-workers from CNRS have reported in ACIE on a ruthenium catalyzed hydrochlorination of alkynes.

 

ACIE paper

Posted in Methodology, Ruthenium, Transition Metal | Leave a Comment »

Bicyclomycin formal synthesis

Posted by naturalproductman on August 26, 2015

Ullrich Jahn and co-workers from the Academy of the Sciences of the Czech Republic reported in ACIE on a formal synthesis of bicyclomycin.
radical
ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Diels-Alder approach to galbulimima alkaloids

Posted by naturalproductman on August 25, 2015

Here’s a paper related to the galbulimima alkaloids, which were made famous by Lewis Mander’s group. Regan Thomson and co-workers report in JACS on the synthesis of galbulimima alkaloids. A nice collaboration with DFT calculations from Dean Tantillo’s group shows the orbital interactions in the transition state structures of the Diels-Alder reactions.
galbulimima

JACS paper

Posted in Alkaloids, DFT, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

retro [2+2] by ultrasonication

Posted by naturalproductman on August 25, 2015

Jeffrey Moore and colleague at UIUC have reported in JACS on a retro Staudinger cycloaddition reaction. I am reminded of the retro-“click” paper.
2+2

JACS paper

Posted in Cycloaddition, Methodology | Leave a Comment »

Mycothiazole synthesis

Posted by naturalproductman on August 21, 2015

Karl Hale and colleague at the Queen’s University Belfast have reported in Organic Letters on the synthesis of mycothiazole.

mycothiazole

OL paper

Posted in Alkaloids, Methodology, Structural Reassignment, Thiazoles, Total Synthesis | Leave a Comment »

Secu’amamine A synthesis

Posted by naturalproductman on August 21, 2015

Amos Smith and colleague have reported in Organic Letters on the synthesis of secu’amamine A.
secu'amamine A
OL paper

Posted in Alkaloids, Methodology, Multi-Component Coupling, Total Synthesis | Leave a Comment »

Pestaloxazine A

Posted by naturalproductman on August 21, 2015

Chang-Lun Shao and co-workers from the Ocean University of China have reported in Organic Letters on the isolation of anti-viral pestaloxazine A.

anti-viral

OL paper

Posted in Anti-viral, C2-Symmetric | Leave a Comment »

Griseusin synthesis

Posted by naturalproductman on August 20, 2015

Jon Thorson and co-workers from the University of Kentucky have reported in ACIE on the syntheses of griseusins.
griseusins
ACIE paper

Posted in C-H activation, Methodology, Polyketides, Total Synthesis | Leave a Comment »

 
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