Naturalproductman’s Blog

Hey, is that a natural product?!

Muironolide A synthesis

Posted by naturalproductman on May 4, 2015

Armen Zakarian and co-workers have reported in JACS on the synthesis of muironolide A.

muironolide A

JACS paper

Posted in Macrolides, Structural Reassignment, Total Synthesis | Leave a Comment »

Gelsemoxonine synthesis

Posted by naturalproductman on May 4, 2015

Erick Carreira and colleague have reported in JACS on the synthesis of gelsemoxonine.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Domino acylation Diels-Alder

Posted by naturalproductman on May 2, 2015

Jeffrey Aube (University of Kansas) and Dean Tantillo (UC Davis) have teamed up to study the mechanism of a domino acylation-Diels Alder reaction.

domino

OL paper

Posted in DFT, Diels-Alder, Mechanistic, Methodology, Named Reactions | Leave a Comment »

Hypervalent iodine towards lactams

Posted by naturalproductman on May 2, 2015

Antonio Herrera and co-workers from CSIC have reported in Organic Letters on a hypervalent iodine approach to access lactams from linear precursors.

OL paper

Posted in Hofmann–Löffler–Freytag-type, Hypervalent Iodine, Methodology, Named Reactions | Leave a Comment »

Oxygen transfer

Posted by naturalproductman on May 2, 2015

Chepuri Ramana and colleague at CSIR have reported in Organic Letters on a ruthenium catalyzed oxygen transfer reaction.
oxygen

OL paper

Posted in Methodology, Ruthenium, Transition Metal | Leave a Comment »

Methylene transfer

Posted by naturalproductman on May 2, 2015

Itaru Nakamura and co-workers from Tohoku University have reported in ACIE on a gold catalyzed methylene transfer sequence to access isoxazolines.

methylene

ACIE paper

Posted in Cascade Reactions, Gold, Methodology, Transition Metal | Leave a Comment »

Serpentine synthesis

Posted by naturalproductman on May 2, 2015

Karl Scheidt and co-workers have reported in ACIE on the synthesis of alstonine and serpentine through cooperative catalysis.
heteroyohimbine
ACIE paper

Posted in Alkaloids, Cooperative Catalysis, Methodology, Total Synthesis | Leave a Comment »

Disorazole synthesis through metathesis

Posted by naturalproductman on May 2, 2015

Alison Hulme and co-workers from the University of Edinburgh have reported in ACIE on a metathesis approach to disorazole. Reminds me of the Hoveyda approach.

metathesis

ACIE paper

Posted in Asymmetric, C2-Symmetric, Metathesis, Methodology, Molybdenum, Transition Metal | Leave a Comment »

Cyclopropanation with iron(III) phthalocyanine

Posted by naturalproductman on May 2, 2015

Emily Balskus and colleague have reported in ACIE on an iron(III) phthalocyanine catalyst that can perform cyclopropanation reactions. Reminds me of the P450 version that was published a few years back.

cyclopropanation
ACIE paper

Posted in Enzymes, Iron, Methodology, Transition Metal | Leave a Comment »

The cousin of the Saegusa-Ito oxidation

Posted by naturalproductman on May 2, 2015

Timothy Newhouse and co-workers at Yale have reported in JACS on an interesting way to make alpha,beta-unsaturated esters and nitriles from saturated starting materials.

unsaturation

JACS paper

Posted in Palladium, Transition Metal | Leave a Comment »

 
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