Naturalproductman’s Blog

Hey, is that a natural product?!

CO-Releasing molecules (CORMs)

Posted by naturalproductman on June 7, 2015

Hans-Günther Schmalz and co-workers from Universität zu Köln have reported in ACIE on some small molecules that release carbon monoxide upon reacting with protease.

CO

ACIE paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Limonin synthesis

Posted by naturalproductman on June 7, 2015

Masahiro Hirama and co-workers at Tohoku University have reported in ACIE on the synthesis of limonin.

limonin

ACIE paper

Posted in Total Synthesis | Leave a Comment »

Cyclic 1,3-carbonates from carbon dioxide fixation

Posted by naturalproductman on June 7, 2015

Jeffrey Johnston and co-workers have reported in JACS on the synthesis of 1,3-cyclic carbonates from butenol, carbon dioxide and NIS.
carbonate
JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Spirooliganone synthesis

Posted by naturalproductman on June 6, 2015

Shishan Yu and co-workers from the Chinese Academy of Sciences at have reported in Organic Letters on the synthesis of spirooliganone, which had 0.41 μM IC50 activity against Coxsackie virus B3.

spirooliganone
OL paper

Posted in Antiviral, Polyketides, Total Synthesis | Leave a Comment »

Kirkamide looks like oseltamivir

Posted by naturalproductman on June 6, 2015

This natural product looks like oseltamivir.
oseltamivir
ACIE paper

Posted in Glycosides | Leave a Comment »

Nanocystin A

Posted by naturalproductman on June 6, 2015

Here’re some macrocycles reported in ACIE.
nanocystin A

ACIE paper

Posted in Antibiotics, Macrocycles | Leave a Comment »

Alzmaphorazine B synthesis

Posted by naturalproductman on June 6, 2015

Christopher Vanderwal and colleague have reported in JACS on a synthesis of alzmaphorazine B.

alkaloid

JACS paper

Posted in Alkaloids, Biosynthesis, Total Synthesis | Leave a Comment »

Ru-catalyzed metathesis of fluoro-olefins and enol ethers

Posted by naturalproductman on June 6, 2015

Yusuke Takahira and colleague at Asahi Glass Co. have reported in JACS on a cross metathesis between fluoro-olefins and enol ethers.

metathesis

JACS paper

Posted in Metathesis, Ruthenium, Transition Metal | Leave a Comment »

Nodulisporic acid D synthesis

Posted by naturalproductman on June 6, 2015

Amos Smith and co-workers have reported in JACS on the synthesis of nodulisporic acid D.

alkaloid

JACS paper

Posted in Alkaloids, Total Synthesis, Transition Metal | Leave a Comment »

Sn2 prime with trichloroacetimidates

Posted by naturalproductman on May 28, 2015

At first look of the abstract figure I thought this was an Overman rearrangement paper but no, trichloroacetimidates are also good leaving groups for Sn2 prime reactions.

Sn2 prime

ACIE paper

Posted in Cascade Reactions, Methodology, Ring forming, Sn2 prime | Leave a Comment »

 
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