Naturalproductman’s Blog

Hey, is that a natural product?!

Lactate dehydrogenase inhibitors for epilepsy

Posted by naturalproductman on March 21, 2015

Tsuyoshi Inoue and co-workers at Okayama University have reported in Science on lactate dehydrogenase inhibition using stiripentol analogs as a strategy to treat epileptic seizures.

Science paper

Posted in Diseases | Leave a Comment »

Schilancitrilactones B and C syntheses

Posted by naturalproductman on March 21, 2015

Pingping Tang and co-workers from Nankai University have reported in ACIE on the synthesis of schilancitrilactones B and C.
Schilancitrilactones B and C

ACIE paper

Posted in Total Synthesis | Leave a Comment »

Bromochlorination of allylic alcohols

Posted by naturalproductman on March 21, 2015

Noah Burns and co-workers at Stanford have reported in JACS on a bromo-chlorination of allylic alcohols.
bromochlorination

JACS paper

Posted in Methodology, Titanium, Transition Metal | Leave a Comment »

Leucosceptroids synthesis

Posted by naturalproductman on March 21, 2015

Thomas Magauer and colleague at Ludwig-Maximilians-University Munich have reported in JACS on the synthesis of leucosceptroids.

leucosceptroid

JACS paper

Posted in Methodology, Total Synthesis | Tagged: | Leave a Comment »

Synthesis of Leupyrrin A1

Posted by naturalproductman on March 21, 2015

Dirk Mensche and co-workers at Universität Bonn have reported in JACS on the synthesis of

synthesis

JACS paper

Posted in Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Terpene cyclization involving carbons switching

Posted by naturalproductman on March 5, 2015

Tomohisa Kuzuyama and co-workers at the University of Tokyo have reported in ACIE on an mechanistically interesting terpene cyclization involving two carbons switching.

terpene

ACIE paper

Posted in Biosynthesis, Enzymes, Mechanistic, Proteins | Leave a Comment »

Diazonamide analogs through electrochemistry

Posted by naturalproductman on March 5, 2015

Patrick Harran and co-workers have reported in ACIE on an electrochemical approach to access diazonamide analogs.
diazonamide
ACIE paper

Posted in Electrochemical, Macrocycles, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Silver mediated (stoichiometric) C-H activation

Posted by naturalproductman on March 5, 2015

Pingping Tang and co-workers from Nankai University have reported in ACIE on a silver mediated trifluoromethylthiolation.

silver

ACIE paper

Posted in C-H activation, Methodology, Silver, Transition Metal | Leave a Comment »

Rh-catalyzed cascade

Posted by naturalproductman on March 5, 2015

P. Andrew Evans and co-workers at Queen’s University have reported in ACIE on a rhodium catalyzed [(3+2)+2] carbocyclization.

rhodium

ACIE paper

Posted in Cascade Reactions, Methodology, Rhodium, Transition Metal | Leave a Comment »

Efavirenz flow synthesis

Posted by naturalproductman on March 5, 2015

Peter Seeberger and co-workers at Max Planck Institute of Colloids and Interfaces have reported in ACIE on the flow synthesis of efavirenz.

flow

ACIE paper

Posted in Flow, HIV, New Setups, Total Synthesis | Leave a Comment »

 
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