Naturalproductman’s Blog

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Archive for December, 2013

Metal-halogen exchange, diastereoselectively

Posted by naturalproductman on December 31, 2013

Paul Knochel and co-workers at LMU Munchen have reported in ACIE on a halogen metal exchange, which occurs with good diastereoselectivity. Be careful t-BuLi is used!

lithium

ACIE paper

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Posted in Diastereoselective, Methodology | Leave a Comment »

Sweriledugenin A

Posted by naturalproductman on December 30, 2013

Ji-Jun Chen and co-workers at the Kunming Institute of Botany have reported in Org Lett on the isolation of sweriledugenin A.

lactone

OL paper

Posted in Anti-viral, Diseases, Lactones, Mass Spectrometry | Leave a Comment »

BINOL + SbCl5

Posted by naturalproductman on December 30, 2013

EJ Corey and co-workers reported in JACS on an antimonate catalyzed cation pi-cyclization.

Sb

JACS paper

Posted in Cascade Reactions, Methodology | Leave a Comment »

Hydroarylation asymmetrically

Posted by naturalproductman on December 27, 2013

Nicolai Cramer and co-workers have reported in ACIE on a rhodium catalyzed enantioselective hydroarylation.

hydroarylation

ACIE paper

Posted in Asymmetric, Hydroarylation, Methodology, Rhodium, Transition Metal | Leave a Comment »

JACS or Angewandte?

Posted by naturalproductman on December 27, 2013

Which journal is better: JACS or ACIE?

I think many people have asked this question before.

ACIE has a higher impact factor than JACS.

Something I do like better about JACS than ACIE is that the supporting information is free to the public.

Posted in Random | 7 Comments »

Indole alkaloids

Posted by naturalproductman on December 17, 2013

Jieping Zhu and co-workers haver reported in JACS on the syntheses of some indole alkaloids.

indole

 

 

JACS paper

Posted in Alkaloids, Indoles, Methodology, Total Synthesis | Leave a Comment »

Hydroboration – interesting

Posted by naturalproductman on December 17, 2013

Paul Chirik and colleague from Princeton have reported in JACS on an interesting hydroboration.

B-H

JACS paper

Posted in Cascade Reactions, Cobalt, Methodology, Transition Metal | Leave a Comment »

Alpha-arylation/N-Alkylation

Posted by naturalproductman on December 17, 2013

Daniel Seidel and co-workers at Rutgers have reported in Organic Letters on an alpha-arylation/N-alkylation reaction.

N-alkylation

OL paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Erythropoietin synthesis

Posted by naturalproductman on December 13, 2013

Danishefsky and co-workers reported in Science on the synthesis of erythropoietin after 1000 steps. Just kidding.

Science paper

Posted in Proteins, Total Synthesis | Leave a Comment »

Anyone else notice?

Posted by naturalproductman on December 13, 2013

Is it just me or does anyone else notice more total syntheses papers in ACIE than in JACS?

Posted in Random, Total Synthesis | Leave a Comment »