Clavolonine Synthesis

Hiromichi Fujioka and co-workers from Osaka University have published in Organic Letters on a total synthesis of clavolonine where they made use of a Staudinger reaction to form one of the piperidines.

OL paper

Indolo[1,2-c]quinazoline Synthesis via Multi-Component Coupling Strategy

Ming-Wu Ding and co-workers from the Central China Normal University have published in Organic and Biomolecular Chemistry on a multi-component coupling approach followed by a Staudinger/Aza-Wittig reaction.

 

OBC paper

Ugi then Staudinger-Aza-Wittig

Tomas Torroba and co-workers from the Universidad de Burgos have published on an Ugi reaction followed by a Staudinger-Aza-Wittig cyclization.  The key was that the carboxylic acid partner in the Ugi reaction was tethered by an azide group.

Tetrahedron paper

Circumdatin H Synthesis

Subhas Bose and co-worker at the Indian Institute of Chemical Technology have recently published in Chemical Communications on the synthesis of circumdatin H, an NADH oxidase inhibitor.  The key reaction was an Eguchi-aza-Wittig reaction to form the carbon nitrogen double bond.

Synthesis paper