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Archive for the ‘Sesquiterpenes’ Category

Corvol ethers A and B biosynthesis

Posted by naturalproductman on March 25, 2015

Jeroen Dickschat and co-workers at Technische Universität Braunschweig have reported in ACIE on some terpene biosynthesis by characterizing a sesquiterpene cyclase enzyme.

terpene
ACIE paper

Posted in Biosynthesis, Enzymes, Sesquiterpenes | Leave a Comment »

Dicarabrones A and B

Posted by naturalproductman on March 21, 2015

Yang Ye and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on isolation of dicarabrones A and B.

lactone

OL paper

Posted in Cancer, Lactones, Sesquiterpenes | Leave a Comment »

Englerin A activates TRPC4 and TRPC5

Posted by naturalproductman on February 23, 2015

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
englerin A

ACIE paper

Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »

Antroquinonol synthesis

Posted by naturalproductman on February 22, 2015

Chinpiao Chen and co-worker from National Dong Hwa University have reported in Organic Letters on the syntheses of antroquinononol and antroquinonol D.

antroquinonol

OL paper

Posted in Iridium, Sesquiterpenes, Total Synthesis, Transition Metal | Leave a Comment »

Transtaganolide syntheses

Posted by naturalproductman on May 17, 2013

Brian Stoltz and co-workers have reported in ACIE on the syntheses of transtaganolides through an Ireland-Claisen rearrangement/Diels-Alder cascade.

ICR/DA

ACIE paper

Posted in Asymmetric, Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Sesquiterpenes, Total Synthesis | Leave a Comment »

Structural reassignment of aquatolide using DFT/NMR

Posted by naturalproductman on November 6, 2012

Dean Tantillo and co-workers have used Gaussian in conjunction with NMR and crystallography to reassign the structure of aquatolide.

structural reassignment

JACS paper

Posted in Computational, DFT, Lactones, Sesquiterpenes | Leave a Comment »

A 5,6,4-tricycle

Posted by naturalproductman on September 7, 2012

Ji-Kai Liu and co-workers from the Kunming Institute of Botany have reported in Organic Letters on the isolation of trefolane.

5,6,4

OL paper

Posted in Sesquiterpenes | Leave a Comment »

Chlorinated englerins

Posted by naturalproductman on February 10, 2012

John Beutler and co-workers from the NCI have reported in the Journal of Natural Products on the isolation of chlorinated englerins and their anti-cancer activities.

chlorinated

JNP paper

Posted in Cancer, renal, Sesquiterpenes, Sesquiterpenoids | Leave a Comment »

Artemisinin chemistry

Posted by naturalproductman on January 17, 2012

Giancarlo Marconi and co-workers have reported in Tetrahedron Letters on a reduction of artemisinin, an antimalarial compound, to break down the peroxide bond and open the ring.

artemisinin

TL paper

Posted in Diseases, Lactones, Malaria, Mechanistic, Sesquiterpenes | Leave a Comment »

Dysidavarones

Posted by naturalproductman on December 2, 2011

Hou-Wen Lin and co-workers at Second Military Medical University have reported in Organic Letters on the isolation of dysidavarones A-D.  Dysidavarones A and B had IC50 values of 9.98 and 21.6 μM towards protein
tyrosine phosphatase 1B (PTP1B).

PTP

OL paper

Posted in Cancer, Enzymes, Protein Targets, protein tyrosine phosphatase 1B (PTP1B), Proteins, Quinones, Sesquiterpenes | Leave a Comment »

 
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