Jeroen Dickschat and co-workers at Technische Universität Braunschweig have reported in ACIE on some terpene biosynthesis by characterizing a sesquiterpene cyclase enzyme.
Archive for the ‘Sesquiterpenes’ Category
Posted by naturalproductman on March 25, 2015
Posted by naturalproductman on March 21, 2015
Yang Ye and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on isolation of dicarabrones A and B.
Posted by naturalproductman on February 23, 2015
Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
Posted by naturalproductman on May 17, 2013
Brian Stoltz and co-workers have reported in ACIE on the syntheses of transtaganolides through an Ireland-Claisen rearrangement/Diels-Alder cascade.
Posted by naturalproductman on November 6, 2012
Dean Tantillo and co-workers have used Gaussian in conjunction with NMR and crystallography to reassign the structure of aquatolide.
Posted by naturalproductman on September 7, 2012
Ji-Kai Liu and co-workers from the Kunming Institute of Botany have reported in Organic Letters on the isolation of trefolane.
Posted by naturalproductman on February 10, 2012
John Beutler and co-workers from the NCI have reported in the Journal of Natural Products on the isolation of chlorinated englerins and their anti-cancer activities.
Posted by naturalproductman on January 17, 2012
Giancarlo Marconi and co-workers have reported in Tetrahedron Letters on a reduction of artemisinin, an antimalarial compound, to break down the peroxide bond and open the ring.
Posted by naturalproductman on December 2, 2011
Hou-Wen Lin and co-workers at Second Military Medical University have reported in Organic Letters on the isolation of dysidavarones A-D. Dysidavarones A and B had IC50 values of 9.98 and 21.6 μM towards protein
tyrosine phosphatase 1B (PTP1B).