Shunichi Hashimoto and co-workers from Hokkaido University have reported in Chemistry a European Journal on their total synthesis of englerin A.
Archive for the ‘Sesquiterpenes’ Category
Posted by naturalproductman on July 20, 2015
Posted by naturalproductman on July 13, 2015
Long-Yi Kong and co-workers from China Pharmaceutical University have reported in Tetrahedron on the isolation of sarglabolides that inhibited NO production (2.33 micromol/L).
Posted by naturalproductman on March 25, 2015
Jeroen Dickschat and co-workers at Technische Universität Braunschweig have reported in ACIE on some terpene biosynthesis by characterizing a sesquiterpene cyclase enzyme.
Posted by naturalproductman on March 21, 2015
Yang Ye and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on isolation of dicarabrones A and B.
Posted by naturalproductman on February 23, 2015
Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
Posted by naturalproductman on May 17, 2013
Brian Stoltz and co-workers have reported in ACIE on the syntheses of transtaganolides through an Ireland-Claisen rearrangement/Diels-Alder cascade.
Posted by naturalproductman on November 6, 2012
Dean Tantillo and co-workers have used Gaussian in conjunction with NMR and crystallography to reassign the structure of aquatolide.