Dictyoxetane synthesis

Thomas Magauer and colleague at LMU have reported in JACS on the synthesis of dictyoxetane.

 

JACS paper

Akaol A synthesis

Alakesh Bisai and co-workers reported in Organic Letters on a Nazarov approach to akaol A.

 

OL paper

Naupliolide A synthesis

Hisanaka Ito and co-workers at Tokyo University of Pharmacy and Life Sciences have reported in ACIE on the synthesis of naupliolide A.

 

ACIE paper

(−)-Jiadifenin synthesis

Glenn Micalizio and colleague at Dartmouth College have reported in JACS on the synthesis of jiadifenin.

 

JACS paper

Englerin A synthesis

Shunichi Hashimoto and co-workers from Hokkaido University have reported in Chemistry a European Journal on their total synthesis of englerin A.

Chemistry – a European Journal paper

Sarglabolides A-K

Long-Yi Kong and co-workers from China Pharmaceutical University have reported in Tetrahedron on the isolation of sarglabolides that inhibited NO production (2.33 micromol/L).

Tetrahedron paper

Guanacastepene syntheses

Chin-Kang Sha and colleague from National Tsing-Hua University have reported in Organic Letters on the syntheses of guanacastapenes N and O.

OL paper

Corvol ethers A and B biosynthesis

Jeroen Dickschat and co-workers at Technische Universität Braunschweig have reported in ACIE on some terpene biosynthesis by characterizing a sesquiterpene cyclase enzyme.

ACIE paper

Dicarabrones A and B

Yang Ye and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on isolation of dicarabrones A and B.

OL paper

Englerin A activates TRPC4 and TRPC5

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.

ACIE paper