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Archive for the ‘Sesquiterpenes’ Category

Englerin A synthesis

Posted by naturalproductman on July 20, 2015

Shunichi Hashimoto and co-workers from Hokkaido University have reported in Chemistry a European Journal on their total synthesis of englerin A.

Chemistry – a European Journal paper

Posted in Sesquiterpenes, Total Synthesis | Leave a Comment »

Sarglabolides A-K

Posted by naturalproductman on July 13, 2015

Long-Yi Kong and co-workers from China Pharmaceutical University have reported in Tetrahedron on the isolation of sarglabolides that inhibited NO production (2.33 micromol/L).

sarglabolides

Tetrahedron paper

Posted in Dimer, Sesquiterpenes | Leave a Comment »

Guanacastepene syntheses

Posted by naturalproductman on July 11, 2015

Chin-Kang Sha and colleague from National Tsing-Hua University have reported in Organic Letters on the syntheses of guanacastapenes N and O.

guanacastepene

OL paper

Posted in Copper, Diels-Alder, Kinetic resolution, Methodology, Named Reactions, Radical Chemistry, Sesquiterpenes, Total Synthesis, Transition Metal | Leave a Comment »

Corvol ethers A and B biosynthesis

Posted by naturalproductman on March 25, 2015

Jeroen Dickschat and co-workers at Technische Universität Braunschweig have reported in ACIE on some terpene biosynthesis by characterizing a sesquiterpene cyclase enzyme.

terpene
ACIE paper

Posted in Biosynthesis, Enzymes, Sesquiterpenes | Leave a Comment »

Dicarabrones A and B

Posted by naturalproductman on March 21, 2015

Yang Ye and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on isolation of dicarabrones A and B.

lactone

OL paper

Posted in Cancer, Lactones, Sesquiterpenes | Leave a Comment »

Englerin A activates TRPC4 and TRPC5

Posted by naturalproductman on February 23, 2015

Herbert Waldmann and co-workers at Max-Planck-Institut fur Molekulare Physiologie have reported in ACIE on the target of englerin A. This report is very interesting. When I think of TRPC channels (Transient receptor potential canonical channels), I usually think of our taste buds and how the different electrophiles activate different tastes (bitterness, etc). I guess this calcium influx kills the cancer cells according to the authors. And some how this is all happening selectively for renal cancer cells and not the other kind of cancer cells.
englerin A

ACIE paper

Posted in Chemical Biology, Protein Targets, Sesquiterpenes | Leave a Comment »

Antroquinonol synthesis

Posted by naturalproductman on February 22, 2015

Chinpiao Chen and co-worker from National Dong Hwa University have reported in Organic Letters on the syntheses of antroquinononol and antroquinonol D.

antroquinonol

OL paper

Posted in Iridium, Sesquiterpenes, Total Synthesis, Transition Metal | Leave a Comment »

Transtaganolide syntheses

Posted by naturalproductman on May 17, 2013

Brian Stoltz and co-workers have reported in ACIE on the syntheses of transtaganolides through an Ireland-Claisen rearrangement/Diels-Alder cascade.

ICR/DA

ACIE paper

Posted in Asymmetric, Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Sesquiterpenes, Total Synthesis | Leave a Comment »

Structural reassignment of aquatolide using DFT/NMR

Posted by naturalproductman on November 6, 2012

Dean Tantillo and co-workers have used Gaussian in conjunction with NMR and crystallography to reassign the structure of aquatolide.

structural reassignment

JACS paper

Posted in Computational, DFT, Lactones, Sesquiterpenes | Leave a Comment »

A 5,6,4-tricycle

Posted by naturalproductman on September 7, 2012

Ji-Kai Liu and co-workers from the Kunming Institute of Botany have reported in Organic Letters on the isolation of trefolane.

5,6,4

OL paper

Posted in Sesquiterpenes | Leave a Comment »

 
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