Q-Z domain of maitotoxin

Nicolaou and co-workers have reported in the synthesis of a Q-Z domain of maitotoxin.

 

JACS paper

Gambieric acid A synthesis

Makoto Sasaki and co-workers at Tohoku University have reported in JACS on the synthesis of gambieric acid A.

JACS paper

Gambierol analogs

Luis Botana and co-workers from Universidad de Santiago de Compostela, Lugo, Spain have reported in JACS on the synthesis of gambierol analogs.

JACS paper

Brevisulcenal F

Brevisulcenal F has been isolated from a dinoflagellate. Masayuki Satake and co-workers from the University of Tokyo have isolated and characterized this deadly compound, which killed many fish in New Zealand.

JACS paper

Halichondrin C synthesis

Yoshito Kishi and co-workers have reported in JACS on the synthesis of halichondrin C.

JACS paper

Oxiranyl anion cascade

Yuji Mori and co-workers at Meijo University have reported in Organic Letters on an approach to tackle the synthesis of cyclic polyethers.

OL paper

Brevenal Synthesis

Jon Rainier and co-workers at Utah have published in JACS on the total synthesis of brevenal.

 

JACS paper

Epoxide Opening Cascade

Timothy Jamison and co-workers have recently published in JOC on a CsF mediated epoxide opening cascade of a polyepoxy molecule that has TMS substituents.

JOC paper

Halichondrin

When an expert in total synthesis such as Kishi has a name on a journal article that is focused on synthesis of natural products, you know it has to be good.  The highlight of this synthesis is really the Ni/Cr catalyzed coupling using an aldehyde and a vinyl iodide.

JACS paper 1

JACS paper 2

Cascade Polyepoxide Opening

Timothy Jamison et. al have published in JACS on a cascade polyepoxide opening reaction to synthesize the 7,7,6-tricyclic ring system of dioxepandehydrothyrsiferol.

JACS paper