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Archive for the ‘Diels-Alder’ Category

Leucoridine synthesis

Posted by naturalproductman on August 28, 2015

Rodrigo Andrade and co-workers from Temple University have reported in ACIE on the synthesis of

Diels-Alder

ACIE paper

Posted in Alkaloids, Diels-Alder, Dimer, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

Diels-Alder approach to galbulimima alkaloids

Posted by naturalproductman on August 25, 2015

Here’s a paper related to the galbulimima alkaloids, which were made famous by Lewis Mander’s group. Regan Thomson and co-workers report in JACS on the synthesis of galbulimima alkaloids. A nice collaboration with DFT calculations from Dean Tantillo’s group shows the orbital interactions in the transition state structures of the Diels-Alder reactions.
galbulimima

JACS paper

Posted in Alkaloids, DFT, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

Guanacastepene syntheses

Posted by naturalproductman on July 11, 2015

Chin-Kang Sha and colleague from National Tsing-Hua University have reported in Organic Letters on the syntheses of guanacastapenes N and O.

guanacastepene

OL paper

Posted in Copper, Diels-Alder, Kinetic resolution, Methodology, Named Reactions, Radical Chemistry, Sesquiterpenes, Total Synthesis, Transition Metal | Leave a Comment »

Domino acylation Diels-Alder

Posted by naturalproductman on May 2, 2015

Jeffrey Aube (University of Kansas) and Dean Tantillo (UC Davis) have teamed up to study the mechanism of a domino acylation-Diels Alder reaction.

domino

OL paper

Posted in DFT, Diels-Alder, Mechanistic, Methodology, Named Reactions | Leave a Comment »

Mogolides A and B syntheses

Posted by naturalproductman on November 28, 2014

Yefeng Tang and co-workers from Tsinghua University have reported in ACIE on the synthesis mogolides A and B.

biomimetic

ACIE paper

Posted in Diels-Alder, Dimer, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Paracaseolide A synthesis

Posted by naturalproductman on October 25, 2014

Goverdhan Mehta (University of Hyderabad) and co-workers at IIT Hyderabad have reported in Tetrahedron on the synthesis of paracaseolide A.
paracaseolide A

Tetrahedron paper

Posted in Diels-Alder, Named Reactions, Total Synthesis | Leave a Comment »

Strained alkynes are in

Posted by naturalproductman on October 25, 2014

Rick Danheiser and colleague have reported in JACS on the synthesis of an aza-cyclohexyne to do the chemistries that other people have been doing with benzynes.

alkyne

JACS paper

Posted in Diels-Alder, Methodology, Named Reactions, [2+2] | Leave a Comment »

Hyperuralones A and B

Posted by naturalproductman on September 8, 2014

Gang Xu and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of hyperuralones A and B, which had low micro molar IC50 activity against cancer cells.

cancer

OL paper

Posted in Cancer, Diels-Alder, Isoprenoids, Named Reactions | Leave a Comment »

Cavicularin synthesis

Posted by naturalproductman on August 18, 2014

Christopher Beaudry and colleague at Oregon State have reported in ACIE on the synthesis of cavicularin through a Diels-Alder with a vinyl sulfone dienophile.

Diels Alder

ACIE paper

Posted in Aromatic, Diels-Alder, Methodology, Total Synthesis | Leave a Comment »

Claisen-Diels-Alder cascade to spirooliganones A and B

Posted by naturalproductman on July 16, 2014

Rongbiao Tong and co-workers from the Hong Kong University of Science and Technology have reported in Org Lett on a slick reaction to form spirooliganones.

 
spirooliganones

OL paper

Posted in Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

 
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