Naturalproductman’s Blog

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Archive for the ‘Polyynes’ Category


Posted by naturalproductman on December 9, 2011

Maria Letizia Ciavatta and co-workers at Istituto di Chimica Biomolecolare in Italy have reported in Tetrahedron on the isolation of fulvyne.


Tetrahedron paper

Posted in Antibiotics, Polyynes | Leave a Comment »

Mollenyne A

Posted by naturalproductman on November 17, 2011

Tadeusz Molinski and colleague at UCSD have reported in Organic Letters on the isolation of mollenyne A which had an IC50 value of 1.3 micrograms/mL against human colon cancer cell lines (HCT-116).


OL paper

Posted in Cancer, colon, Polyynes | Leave a Comment »


Posted by naturalproductman on November 9, 2011

Hiroshi Nakano and co-workers at NARO Kyushu Okinawa Agricultural Research Center have reported in Organic Letters on the isolation of some thiophene containing natural products that killed termites.

OL paper

Posted in Polyynes, Thiophenes | Leave a Comment »

A drug for drugs

Posted by naturalproductman on August 24, 2011

You may have seen this in C&E News but for those who missed it:  Danishefsky and co-workers have reported in PNAS on a ginseng analog (poly alkyne) that reduces the side effects of chemotherapy and X-ray treatments.  If you look at the data, then I wouldn’t conclude that the compound drastically improved the side effects of taxol, X-ray and other treatments (3-5% improvement in weight loss, etc), but the idea is interesting and it is a start.


PNAS paper

Posted in Polyynes, Unnatural Products | Leave a Comment »

Cytopiloyne synthesis

Posted by naturalproductman on June 19, 2011

Jinq-Chyi Lee and co-workers at the Institute of Biotechnology and Pharmaceutical research in Taiwan have reported in Chemistry a European Journal on a polyne natural product that has anti-diabetic activity.


Chemistry a European Journal paper

Posted in Diabetes Type 2, Diseases, Glycosides, Polyynes | Leave a Comment »