Gabriele Konig and co-workers at the University of Bonn in Germany have published in Organic and Biomolecular Chemistry on the isolation of phenalenone derivatives from marine-derived fungus Coniothyrium cereale that were found to inhibit human leukocyte elastase (HLE) at 7.2 to 10.9 micromolar IC50 values. The activity of HLE, a chymotrypsin, has implications in pulmonary emphysema, rheumatoid arthritis, and cystic fibrosis.
Archive for the ‘human leukocyte elastase’ Category
Phenalenone Derivatives
Posted by naturalproductman on January 24, 2011
Posted in Aromatic, Arthritis, Cystic Fibrosis, Diseases, Emphysema, human leukocyte elastase, Phenalenones, Polyketides, Protein Targets | Leave a Comment »
Naturalproductman's Blog 