Naturalproductman’s Blog

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Archive for July, 2015

Pallambins A and B syntheses

Posted by naturalproductman on July 31, 2015

Erick Carreira and colleague have reported in ACIE on the synthesis of pallambin.
pallambin

ACIE paper

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Posted in Electrocyclization, Methodology, Total Synthesis | Leave a Comment »

Ni-catalyzed cyclopropanation

Posted by naturalproductman on July 30, 2015

Peter Chen and co-workers from ETH Zurich have reported in ACIE on a nickel catalyzed cyclopropanation. Looks similar to a Corey-Chaykovsky cyclopropanation because of the formation of an ylide.

nickel

ACIE paper

Posted in Carbene, Cascade Reactions, Methodology, Nickel, Transition Metal | Leave a Comment »

Hydroamidocarbonylation

Posted by naturalproductman on July 30, 2015

Matthias Keller and co-workers have reported in ACIE on a hydroamidocarbonylation of olefins.
hydroamidocarbonylation

ACIE paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Cannizzaro cascade

Posted by naturalproductman on July 30, 2015

Simon Woodward and co-workers have reported in ACIE on a Cannizzaro cascade reaction using tert-butyl lithium.
cascade
ACIE paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

4pi-Electrocyclic ring opening cascade

Posted by naturalproductman on July 23, 2015

Kiyosei Takasu and co-workers from Kyoto University have reported in JACS on a ring expansion cross coupling cascade.

JACS paper

Posted in Cascade Reactions, Electrocyclization, Methodology, Palladium, Transition Metal | Leave a Comment »

Oridamycin synthesis

Posted by naturalproductman on July 22, 2015

Another solo performance from Danishefsky’s lab published by Adam Trotta.

OL paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

What kind of heterocycles are in drugs?

Posted by naturalproductman on July 22, 2015

This is a good review by Jon Njardarson and co-workers in Journal of Medicinal Chemistry on the analysis of heterocycles in FDA approved drugs.
heterocycles
JMC paper

Posted in Medicinal Chemistry | Leave a Comment »

Penibruguieramine A synthesis

Posted by naturalproductman on July 22, 2015

Sanghee Kim and co-workers from Seoul National University have reported in ACIE on the synthesis of penibruguieramine A.

alkaloid

ACIE paper

Posted in Alkaloids, Asymmetric, Kinetic resolution, Methodology, Total Synthesis | Leave a Comment »

Hosieine A synthesis

Posted by naturalproductman on July 22, 2015

Ran Hong and co-workers at SIOC have reported in ACIE on the synthesis of hosieine A. The pyridone moiety reminds of lyconadin.

alkaloid

ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Englerin A synthesis

Posted by naturalproductman on July 20, 2015

Shunichi Hashimoto and co-workers from Hokkaido University have reported in Chemistry a European Journal on their total synthesis of englerin A.

Chemistry – a European Journal paper

Posted in Sesquiterpenes, Total Synthesis | Leave a Comment »