Erinacine S

Chien-Chang Shen and co-workers from Hung Kuang University and National Yang-Ming University in Taiwan have reported in the Journal of Natural Products on the isolation of erinacine S, which had increased the expression of an insulin-degrading enzyme in the cerebral cortex.

JNP paper

Phyllospongin D has a cyclobutane

Rabab Mohammed and co-workers from Beni-Suef University in Egypt have reported in Tetrahedron on the isolation of some sesterterpenes from an Egyptian marine sponge.

Tetrahedron paper

Schisanwilsonene A synthesis

Antonio Echavarran and co-workers at ICIQ have reported in ACIE on a synthesis of schisanwilsonene A.

ACIE paper

Looks like guanacastepene

Asperterpenols A and B were isolated from a mangrove fungus.

OL paper

Not just isolating small molecules anymore…

Hideaki Oikawa and co-workers from Hokkaido University have reported in Organic Letters on the isolation of an enzyme that was known to produce some natural products. They expressed and purified the enzyme, incubated the enzyme in the presence of substrates:  geranyl diphosphate (GPP) and isopentenyl diphosphate (IPP), and examined the products.

OL paper