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Archive for the ‘Classical rules’ Category

Nahuoic acid

Posted by naturalproductman on February 3, 2016

Raymond Andersen and co-workers reported in JOC on the isolation of nahuoic acid. They used Rychnovsky’s method to determine the relative stereochemistry of the alcohols.


JOC paper

Posted in Cancer, Classic papers, Classical rules, Polyketides, Protein Targets, Rycnovsky's rules | Leave a Comment »

Allylboration through Z-T TS

Posted by naturalproductman on May 6, 2014

Kalman Szabo and coworkers from Stockholm University have reported in Chemical Science on an allylboration selective for the anti-product, which can be explained by the Zimmerman-Traxler transition state.


Chemical Science paper

Posted in Classical rules, Methodology, Zimmerman-Traxler transition state | Leave a Comment »

Rules are made to be broken

Posted by naturalproductman on May 6, 2014

Craig Williams and co-workers from the University of Queensland have reported in ACIE on the isolation of EBC-219, a diterpene possessing a bridge head olefin.


ACIE paper

Posted in Bredt's, Classical rules, Diterpene | Leave a Comment »