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Archive for the ‘Classical rules’ Category

Nahuoic acid

Posted by naturalproductman on February 3, 2016

Raymond Andersen and co-workers reported in JOC on the isolation of nahuoic acid. They used Rychnovsky’s method to determine the relative stereochemistry of the alcohols.

 

JOC paper

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Posted in Cancer, Classic papers, Classical rules, Polyketides, Protein Targets, Rycnovsky's rules | Leave a Comment »

Allylboration through Z-T TS

Posted by naturalproductman on May 6, 2014

Kalman Szabo and coworkers from Stockholm University have reported in Chemical Science on an allylboration selective for the anti-product, which can be explained by the Zimmerman-Traxler transition state.

ZT

Chemical Science paper

Posted in Classical rules, Methodology, Zimmerman-Traxler transition state | Leave a Comment »

Rules are made to be broken

Posted by naturalproductman on May 6, 2014

Craig Williams and co-workers from the University of Queensland have reported in ACIE on the isolation of EBC-219, a diterpene possessing a bridge head olefin.

 
bridgehead

ACIE paper

Posted in Bredt's, Classical rules, Diterpene | Leave a Comment »