Regioselective epoxide opening

Pilar López-Ram-de-Víu and co-workers have reported in Organic and Biomolecular Chemistry on an epoxide opening reaction using a Grignard reagent – and the regioselectivity is switched when they use it in the presence of copper bromide.

OBC paper

Kumada Coupling with Retention

Mark Biscoe and co-workers have published in JACS on a Kumada coupling between an aryl bromide or triflate and an sp3-Grignard involving a nickel catalyst and a carbene ligand.

JACS paper

Cascade with Grignard

Ben Feringa and co-workers at have reported in ACIEE on a cascade reaction that involves the conjugate addition of a Grignard followed by an oxidative cyclization.

ACIEE paper

New Tricks with Grignard

Chenzhong Cao and co-workers at Hunan University of Science and Technology have published in Organic Letters on a Grignard addition onto isopropenyl acetate to form 1,3-diols.

 

OL paper

Grignard Approach for Olefination

Songlin Zhang and co-workers from the Chemical Engineering and Materials Science of Soochow University have recently reported in Organic and Biomolecular Chemistry on an olefination process that involved the addition of a Grignard reagent onto a ketone.  The reaction forms an alkene in the presence of diethyl phosphite.

OBC paper