Pilar López-Ram-de-Víu and co-workers have reported in Organic and Biomolecular Chemistry on an epoxide opening reaction using a Grignard reagent – and the regioselectivity is switched when they use it in the presence of copper bromide.
Posted by naturalproductman on December 17, 2010
Chenzhong Cao and co-workers at Hunan University of Science and Technology have published in Organic Letters on a Grignard addition onto isopropenyl acetate to form 1,3-diols.
Posted by naturalproductman on April 22, 2010
Songlin Zhang and co-workers from the Chemical Engineering and Materials Science of Soochow University have recently reported in Organic and Biomolecular Chemistry on an olefination process that involved the addition of a Grignard reagent onto a ketone. The reaction forms an alkene in the presence of diethyl phosphite.