Regioselective acylation

Takeo Kawabata and co-workers from Kyoto University have reported in ACIE on the synthesis of multifidosides through a regioselective acylation.

ACIE paper

Alkoxycarbonylation of allenes – regioselective switching by ligand

Matthias Beller and co-workers have reported in JACS on a ligand controlled regioselectivitiy switching of an alkoxycarbonylation of an allene substrate.

JACS paper

Gold catalyzed spiroketalization

Aaron Aponick and co-workers from the University of Florida have used a trimethylphosphine additive to improve the gold catalyzed spiroketalization for spirastrellolide.

OL paper

Selective acylation of a sugar (1 out of 6)

Kana Sureshan and co-workers from the Indian Institute of Science Education and Research have reported in Chemical Communications on the use of a sulfuric acid/silica gel catalyst to acylate the 2-hydroxy group of inositol.

Chem Comm paper

Regioselective epoxide opening

Pilar López-Ram-de-Víu and co-workers have reported in Organic and Biomolecular Chemistry on an epoxide opening reaction using a Grignard reagent – and the regioselectivity is switched when they use it in the presence of copper bromide.

OBC paper

Regioselective epoxide opening for lysergic acid

Hiroaki Ohno and co-workers from Kyoto University have reported in JOC on their total synthesis of lysergic acid via a regioselective epoxide opening using a reducing agent.

JOC paper

Ir-Catalyzed Allylic Hydroxylation

Gunter Helmchen Organisch-Chemisches Institut der Ruprecht-Karls-Universitat Heidelberg in Germany have published in JACS on an asymmetric allylic hydroxylation reaction starting from an allylic bicarbonate.

 

JACS paper

Isokidamycin Synthesis

Stephen Martin and co-workers have published in JACS on the synthesis of isokidamycin.  They used a silicon tether to perform a regioselective Diels-Alder reaction.

 

JACS paper