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Archive for the ‘Metathesis’ Category

Mycalolides synthesis

Posted by naturalproductman on October 9, 2015

Hideo Kigoshi and co-workers from the University of Tsukuba have reported in ACIE on the synthesis of mycalolides.

oxazole

ACIE paper

Posted in Macrocycles, Metathesis, Methodology, Oxazoles, Ruthenium, Total Synthesis | Leave a Comment »

Pseudotabersonine via double ring closing metathesis

Posted by naturalproductman on August 19, 2015

Stephen Martin and co-workers reported in Tetrahedron on the synthesis of pseudotabersonine using a double ring closing metathesis approach.

double RCM

Tetrahedron paper

Posted in Alkaloids, Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

Ru-catalyzed metathesis of fluoro-olefins and enol ethers

Posted by naturalproductman on June 6, 2015

Yusuke Takahira and colleague at Asahi Glass Co. have reported in JACS on a cross metathesis between fluoro-olefins and enol ethers.

metathesis

JACS paper

Posted in Metathesis, Ruthenium, Transition Metal | Leave a Comment »

Disorazole synthesis through metathesis

Posted by naturalproductman on May 2, 2015

Alison Hulme and co-workers from the University of Edinburgh have reported in ACIE on a metathesis approach to disorazole. Reminds me of the Hoveyda approach.

metathesis

ACIE paper

Posted in Asymmetric, C2-Symmetric, Metathesis, Methodology, Molybdenum, Transition Metal | Leave a Comment »

A Formal Metathesis

Posted by naturalproductman on April 16, 2015

Zhang Jie-Shi and co-workers from the Chinese Academy of Sciences have reported in JACS on a rhodium catalyzed exchange between an aryl keton and an aryl carboxylic acid to form aliphatic carboxylic acids and biaryl compounds.

cascade

JACS paper

Posted in Cascade Reactions, Metathesis, Methodology, Rhodium, Transition Metal | Leave a Comment »

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Neopeltolide through metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers have reported in ACIE on the synthesis of neopeltolide.

metathesis

ACIE paper

Posted in Metathesis, Methodology, Ruthenium, Total Synthesis, Transition Metal | Leave a Comment »

Disorazole through cross metathesis

Posted by naturalproductman on November 8, 2014

Hoveyda and co-workers from Boston College have reported in JACS on a Z-selective cross coupling to access this C2-symmetric molecule – using alkenyl boronate and alkenyl iodide moieties.
metathesis

JACS paper

Posted in Alkaloids, C2-Symmetric, Metathesis, Methodology, Oxazoles, Ruthenium, Transition Metal | Leave a Comment »

Cascade metathesis towards humulanolides

Posted by naturalproductman on October 4, 2014

Chuang-Chuang Li and co-workers at the University of Science and Technology have reported in JACS on a cascade metathesis approach to the synthesis of humulanolides.

metathesis

JACS paper

Posted in Cascade Reactions, Humulanolides, Metathesis, Methodology | Leave a Comment »

Asymmetric metathesis

Posted by naturalproductman on September 8, 2014

Grubbs and colleagues have reported in JACS on their studies with asymmetric ring closing metathesis.

asymmetric

JACS paper

Posted in Asymmetric, Cascade Reactions, Metathesis, Methodology, Ring Opening | 1 Comment »