Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for May, 2016

Darwinolide

Posted by naturalproductman on May 30, 2016

Bill Baker and co-workers at the University of South Florida have reported in Organic Letters on the isolation of darwinolide from an antarctic sponge that inhibited methicillin-resistant S. aureus biofilm formation.

 

OL paper

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Posted in Antibiotics, Diterpene, Lactones | Leave a Comment »

Vancomycin derivative

Posted by naturalproductman on May 29, 2016

Here’s a report on a vancomycin derivative with a pyrophosphate binding group reported by Jayanta Haldar and co-workers at Jawaharlal Nehru Centre for Advanced Scientific Research.

 

ACIE paper

Posted in Antibiotics, Peptides, Unnatural Products | Leave a Comment »

Cannabimovone synthesis

Posted by naturalproductman on May 29, 2016

Antonio Echavarran and co-workers from ICIQ have reported in ACIE on the synthesis of cannabimovone.

 

ACIE paper

Posted in alkyne, Cascade Reactions, Gold, Methodology, Structural Reassignment, Total Synthesis | Leave a Comment »

Perioconiasins A-E syntheses

Posted by naturalproductman on May 29, 2016

Yefeng Tang and co-workers from Tsinghua University have reported in ACIE on the syntheses of perioconiasins A-E.

 

ACIE paper

Posted in Total Synthesis | Leave a Comment »

Erythrina alkaloid syntheses

Posted by naturalproductman on May 29, 2016

Tohru Fukuyama and co-workers reported in ACIE on the syntheses of erythrina alkaloids.

ACIE paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Perforanoid A synthesis

Posted by naturalproductman on May 29, 2016

Xiaojiang Hao and co-workers from the Chinese Academy of Sciences have reported in ACIE on the synthesis of perforanoid A.

 

ACIE paper

Posted in Limonoids, Methodology, Pauson-Khand, Total Synthesis | Leave a Comment »

Towards indoxamycin via C-H functionalization

Posted by naturalproductman on May 29, 2016

Erik Sorensen and Huw Davies and co-workers reported in ACIE on a C-H functionalization approach towards indoxamycin.

 

ACIE paper

Posted in C-H activation, Cascade Reactions, Methodology | Leave a Comment »

Methyl ether + Grignard

Posted by naturalproductman on May 29, 2016

Naoto Chatani and co-workers from Osaka University have reported in JACS on a methyl ether coupling reaction with a Grignard reagent.

 

JACS paper

Posted in cross coupling, Methodology, Nickel, Transition Metal | Leave a Comment »

Towards eribulin

Posted by naturalproductman on May 29, 2016

Yoshito Kishi and colleague have reported in JACS on a coupling reaction between a thioester and an alkyl bromide.

 

JACS paper

Posted in Cascade Reactions, Methodology, Radical Chemistry | Leave a Comment »

Callyspongiolide synthesis

Posted by naturalproductman on May 29, 2016

Tao Ye and co-workers from Peking University have reported in JACS on the synthesis of callyspongiolide.

 

JACS paper

Posted in Alkynes, Macrolides, Polyketides, Total Synthesis | Leave a Comment »