Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Butenolides’ Category

Eutypoids B-E

Posted by naturalproductman on December 6, 2010

Johannes Imhoff and co-workers at Leibniz-Institute of Marine Sciences have published in the Journal of Natural Products on the isolation of eutypoids B-E from the Penicillium sp. strain KF620 i.  Eutypoid B had an IC50 of 0.78 micromolar against glycogen synthase kinase-3β (GSK-3β), which is a target for treating type 2 diabetes and Alzheimer’s disease.


JNP paper

Posted in Alzheimer's, Aromatic, Butenolides, Diabetes Type 2, Diseases, glycogen synthase kinase-3β (GSK-3β), Protein Targets | Leave a Comment »