Naturalproductman’s Blog

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Archive for the ‘Proteins’ Category

Enzyme from bacteria breaks down nicotine

Posted by naturalproductman on August 7, 2015

I’m sure this is not what the authors meant by battling nicotine addiction, but it made me laugh to think that a bacterial enzyme will be responsible to fight nicotine addiction – and immediately I thought that are we going to spray the smokers with this bacteria that has this enzyme?

 
enzyme
JACS paper

Posted in Enzymes | Leave a Comment »

Welcome to the future

Posted by naturalproductman on August 7, 2015

I read the title of this paper and immediately thought of David Baker’s work. I guess we are getting closer to having a logical approach available to design our own protein catalysts.
design
JACS paper

Posted in Computational, Enzymes, Methodology | 2 Comments »

Cyclopropanation with iron(III) phthalocyanine

Posted by naturalproductman on May 2, 2015

Emily Balskus and colleague have reported in ACIE on an iron(III) phthalocyanine catalyst that can perform cyclopropanation reactions. Reminds me of the P450 version that was published a few years back.

cyclopropanation
ACIE paper

Posted in Enzymes, Iron, Methodology, Transition Metal | Leave a Comment »

MAP4K4 for neurodegenerative diseases

Posted by naturalproductman on April 26, 2015

Herbert Waldmann and co-workers at Technische Universität Dortmund have reported in ACIE on MAP4K4 as a target for neurodegenerative diseases.

MAP

ACIE paper

Posted in Diseases, Medicinal Chemistry, Neurodegenerative, Protein Targets, Proteins | Leave a Comment »

Eudistidine A

Posted by naturalproductman on April 20, 2015

The NCI does some nice work with natural products. Kirk Gustafson and co-workers at Bethesda have reported in JACS on some new natural products that block the interaction between p300 and HIF1alpha.

70

JACS paper

Posted in Alkaloids, Protein-Protein Interaction, Proteins, Total Synthesis | Leave a Comment »

Penitrem biosynthesis

Posted by naturalproductman on April 12, 2015

Hideaki Oikawa and co-workers at Hokkaido University have reported in ACIE on the enzymatic biosynthesis of penitrem.

alkaloid

ACIE paper

Posted in Biosynthesis, Cyclobutanes, Diterpene, Enzymes, Indoles | Leave a Comment »

Corvol ethers A and B biosynthesis

Posted by naturalproductman on March 25, 2015

Jeroen Dickschat and co-workers at Technische Universität Braunschweig have reported in ACIE on some terpene biosynthesis by characterizing a sesquiterpene cyclase enzyme.

terpene
ACIE paper

Posted in Biosynthesis, Enzymes, Sesquiterpenes | Leave a Comment »

Terpene cyclization involving carbons switching

Posted by naturalproductman on March 5, 2015

Tomohisa Kuzuyama and co-workers at the University of Tokyo have reported in ACIE on an mechanistically interesting terpene cyclization involving two carbons switching.

terpene

ACIE paper

Posted in Biosynthesis, Enzymes, Mechanistic, Proteins | Leave a Comment »

Cycloclavine biosynthesis

Posted by naturalproductman on March 5, 2015

Sarah O’Connor and co-workers from the John Innes Centre in the UK have reported in ACIE on the biosynthesis of cycloclavine.

cycloclavine

ACIE paper

Posted in Alkaloids, Biosynthesis, Enzymatic, Enzymes, Methodology | Leave a Comment »

Erythropoietin synthesis

Posted by naturalproductman on December 13, 2013

Danishefsky and co-workers reported in Science on the synthesis of erythropoietin after 1000 steps. Just kidding.

Science paper

Posted in Proteins, Total Synthesis | Leave a Comment »

 
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