Jeremy Robertson and co-workers at the University of Oxford have reported in Organic Letters on the synthesis of NP25302 taking advantage of a TMSOTf mediated 5-endo-dig cyclization followed by a Curtius rearrangement to form the Csp2-nitrogen bond.
Archive for the ‘Curtius rearrangement’ Category
NP25302 synthesis
Posted by naturalproductman on October 19, 2011
Posted in Alkaloids, Cancer, Cascade Reactions, Curtius rearrangement, leukemia, Methodology, Named Reactions | Leave a Comment »
Pancrastatin synthesis
Posted by naturalproductman on October 11, 2011
Cheon-Gyu Cho at Hanyang University in Korea have reported in Organic Letters on their synthesis of pancrastatin.
Posted in Alkaloids, Bischler-Napieralski reaction, Cascade Reactions, Curtius rearrangement, Cycloaddition, Diels-Alder, Methodology, Named Reactions, Pericyclic reactions | Leave a Comment »
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