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Posted by naturalproductman on June 3, 2010

Andrew Sutherland and co-workers at the University of Glasgow have published in OBC on a sequence that involves a palladium catalyzed Overman rearrangement followed by ring closing metathesis and a Kharasch cyclization to yield a lactam.


OBC paper

Posted in Cascade Reactions, Kharasch cyclization, Metathesis, Methodology, Named Reactions, Overman rearrangement, Palladium, Pericyclic reactions, Ring forming, Ruthenium, Sigmatropic Rearrangements, Transition Metal | Leave a Comment »