Artemisinin semi-synthesis

Newman and co-workers at Amyris have reported their large scale semi synthesis of artemisinin.

Nature paper

Echinocandin C synthesis

Markus Oberthür and colleague at Philipps-Universität Marburg reported in ACIE on the synthesis of echinocandin C.

ACIE paper

WF-1360F synthesis

Karl-Heinz Altmann and co-workers at have reported in ACIE on the synthesis of WF-1360F.

ACIE paper

Rh-cascade

Ken Tanaka and co-workers at the Tokyo University of Agriculture and Technology have reported in Org Lett on a rhodium catalyzed cascade reaction to yield substituted cyclopentanones.

OL paper

Vinocrine synthesis

David Macmillan and colleague have reported in JACS on a synthesis of vinocrine.

JACS paper

Fluorination using N-OH

Masayuki Inoue and co-workers at the University of Tokyo have reported in Organic Letters on a fluorination of a C-H bond using an N-hydroxy reagent.

OL paper

Asymmetric epoxidation

Benjamin List and co-workers have reported in JACS on their studies of cinchona alkaloid catalyzed asymmetric epoxidation of activated olefins.

JACS paper

Anyone having issues with Scifinder? TRY CAS STRUCTURE EDITOR

Scifinder is a great tool for looking up literature precedence for reactions.  The frustrating part is when I get that message:  “A Java plug-in is required for structure drawing. Refer to the Help.”

In my head I am already saying “I just downloaded that last week!!!”

Apparently there is a new CAS structure editor program you can download – it is pretty much the same thing that comes up in the web based Scifinder version.  The annoying part is that you have to open this program separately from Scifinder and save the file then put the file on the Reaction Structure search option in Scifinder (only .cxf file is supported).

CAS structure editor download link

https://www.cas.org/products/scifinder/system-requirements-web

 

***Recently, it has come to my attention from a good friend that you can just click on the apple symbol if you use safari and the second option down it says, “Software Update…” and this will enable the CAS structure editor on the web-based Scifinder version.

Polycarpathiamines A and B

Peter Proksch and co-workers from Heinrich-Heine University have reported in OL on the isolation of an interesting looking thiadiazole compound.

OL paper

Griseusin B progress

Margaret Brimble and colleague have reported in Org Lett on their strategy for griseusin B.

OL paper