Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for April, 2013

Artemisinin semi-synthesis

Posted by naturalproductman on April 25, 2013

Newman and co-workers at Amyris have reported their large scale semi synthesis of artemisinin.

Nature paper

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Posted in Chemical Biology | Leave a Comment »

Echinocandin C synthesis

Posted by naturalproductman on April 23, 2013

Markus Oberthür and colleague at Philipps-Universität Marburg reported in ACIE on the synthesis of echinocandin C.

echinocandin C

ACIE paper

Posted in Methodology, Peptides | Leave a Comment »

WF-1360F synthesis

Posted by naturalproductman on April 23, 2013

Karl-Heinz Altmann and co-workers at have reported in ACIE on the synthesis of WF-1360F.

WF-1360F

ACIE paper

Posted in Macrolides, Metathesis, Methodology, Total Synthesis | Leave a Comment »

Rh-cascade

Posted by naturalproductman on April 22, 2013

Ken Tanaka and co-workers at the Tokyo University of Agriculture and Technology have reported in Org Lett on a rhodium catalyzed cascade reaction to yield substituted cyclopentanones.

rh

OL paper

Posted in Cascade Reactions, Claisen rearrangement, Methodology, Named Reactions, Rhodium, Transition Metal | Leave a Comment »

Vinocrine synthesis

Posted by naturalproductman on April 22, 2013

David Macmillan and colleague have reported in JACS on a synthesis of vinocrine.

vinocrine

JACS paper

Posted in Alkaloids, Asymmetric, Cascade Reactions, Methodology | Leave a Comment »

Fluorination using N-OH

Posted by naturalproductman on April 19, 2013

Masayuki Inoue and co-workers at the University of Tokyo have reported in Organic Letters on a fluorination of a C-H bond using an N-hydroxy reagent.

fluorination

OL paper

Posted in C-H activation, Methodology | Leave a Comment »

Asymmetric epoxidation

Posted by naturalproductman on April 19, 2013

Benjamin List and co-workers have reported in JACS on their studies of cinchona alkaloid catalyzed asymmetric epoxidation of activated olefins.

cinchona

JACS paper

Posted in Asymmetric, Computational, DFT, ESI, Mass Spectrometry, Mechanistic, Methodology, Organocatalytic | Leave a Comment »

Anyone having issues with Scifinder? TRY CAS STRUCTURE EDITOR

Posted by naturalproductman on April 19, 2013

Scifinder is a great tool for looking up literature precedence for reactions.  The frustrating part is when I get that message:  “A Java plug-in is required for structure drawing. Refer to the Help.”

In my head I am already saying “I just downloaded that last week!!!”

Apparently there is a new CAS structure editor program you can download – it is pretty much the same thing that comes up in the web based Scifinder version.  The annoying part is that you have to open this program separately from Scifinder and save the file then put the file on the Reaction Structure search option in Scifinder (only .cxf file is supported).

CAS structure editor download link

https://www.cas.org/products/scifinder/system-requirements-web

 

***Recently, it has come to my attention from a good friend that you can just click on the apple symbol if you use safari and the second option down it says, “Software Update…” and this will enable the CAS structure editor on the web-based Scifinder version.

Posted in Random | 3 Comments »

Polycarpathiamines A and B

Posted by naturalproductman on April 18, 2013

Peter Proksch and co-workers from Heinrich-Heine University have reported in OL on the isolation of an interesting looking thiadiazole compound.

thiadiazole

OL paper

Posted in Alkaloids, Cancer, Thiadiazoles | Leave a Comment »

Griseusin B progress

Posted by naturalproductman on April 18, 2013

Margaret Brimble and colleague have reported in Org Lett on their strategy for griseusin B.

griseusin B

OL paper

Posted in Methodology, Spiroketals | Leave a Comment »