Marcel Jaspars and co-workers at the University of Aberdeen have reported in the Journal of Natural Products on the isolation of chaxamycin
Archive for the ‘Hsp90’ Category
Chaxamycins
Posted by naturalproductman on May 12, 2011
Posted in Hsp90, Polyketides, Protein Targets | Leave a Comment »
Gambogic acid targets Hsp90
Posted by naturalproductman on April 12, 2011
Hsp90 is a heat shock protein that is 90 kDa (for non biologists: average amino acid molecular weight is approximately 110 Da – Da: daltons). Hsp90 is a chaperone protein that is involved in a complex of other proteins that function to help fold, activate, and stabilize many other proteins that are involved in signal transduction. Robert Matts and co-workers from Oklahoma State University have reported in the Journal of Natural Products on the complex between gambogic acid to the N-terminal domain of Hsp90.
Posted in Cancer, Chemical Biology, Hsp90, Protein Targets, Triterpenes | Leave a Comment »
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