Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for November, 2014

Combining chemical and enzymatic synthesis

Posted by naturalproductman on November 29, 2014

Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.

marineosin

JOC paper

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Posted in Alkaloids, Chemical Biology, Enzymatic, Methodology, Total Synthesis, Unnatural Products | 1 Comment »

Dibromoalkenes from alkynes

Posted by naturalproductman on November 29, 2014

Weimin He and co-workers from Hunan University have reported in JOC on the synthesis of E-dibromoalkenes from alkynes using CuBr2.
copper

JOC paper

Posted in Cascade Reactions, Copper, Methodology, Transition Metal | Leave a Comment »

Propargylamines via multi-component approach

Posted by naturalproductman on November 29, 2014

Zhihua Sun and co-workers from the Shanghai University of Engineering Science have reported in JOC on a multicomponent approach to substituted propargylamines.

MCC

JOC paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

Cochliomycin synthesis via NHK

Posted by naturalproductman on November 29, 2014

Martin Banwell and co-workers at the Australian National University have reported in JOC on the synthesis of cochliomycins A and B.

cochliomycins

JOC paper

Posted in cross coupling, Macrolides, Metathesis, Methodology, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Perophoramidine synthesis

Posted by naturalproductman on November 29, 2014

Barry Trost and co-workers have reported in Chemical Science on the synthesis of perophoramidine.

perophoramidine

Chemical Science paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

Aza-Nazarov

Posted by naturalproductman on November 29, 2014

G Sekar and co-workers from IIT Madras have reported in Chem Comm on an aza-Nazarov cyclization.

Chem Comm paper

Posted in Electrocyclization, Methodology, Named Reactions, Nazarov cyclization | Leave a Comment »

Pyridinium leaving group

Posted by naturalproductman on November 29, 2014

Philip Albiniak and colleagues at Ball State University have reported in Tetrahedron Letters on the synthesis of tert-butyl ethers using a pyridinium leaving group.

tertbutyl

TL paper

Posted in Cascade Reactions, Methodology | 1 Comment »

Multi-component coupling with cobalt

Posted by naturalproductman on November 28, 2014

Xiaobing Wan and co-workers from Soochow University have reported in ACIE on a multi-component coupling approach to access β-Ester-γ-amino ketones.

tbhp

ACIE paper

Posted in Cascade Reactions, Cobalt, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

N-Tosyl hydrazones to alkynes with copper

Posted by naturalproductman on November 28, 2014

Huanfeng Jiang and co-workers from South China University of Technology have reported in ACIE on a copper catalyzed conversion of N-tosyl hydrazones to alkynes. The problem is I don’t know how regioselective this is.

copper

ACIE paper

Posted in Copper, Methodology, Transition Metal | 1 Comment »

Lipiarmycin synthesis

Posted by naturalproductman on November 28, 2014

Jieping Zhu and co-workers at CNRS EPFL-SB-ISIC-LSPN have reported in ACIE on the synthesis of lipiarmycin.

polyketide

ACIE paper

Posted in Glycosides, Methodology, Polyketides, Total Synthesis | 2 Comments »