Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for February, 2016

(−)-Aspidophylline A synthesis

Posted by naturalproductman on February 24, 2016

Yu-Rong Yang and co-workers from the Chinese Academy of Sciences have reported in ACIE on the synthesis of aspidophylline A.

 

 

ACIE paper

Advertisements

Posted in Alkaloids, Iridium, Methodology, Total Synthesis, Transition Metal | Leave a Comment »

Haliclonin A synthesis

Posted by naturalproductman on February 24, 2016

Pei-Qiang Huang and co-workers from Xiamen University have reported in ACIE on the synthesis of haliclonin A.

 

ACIE paper

Posted in Alkaloids, Methodology, Organocatalytic, Total Synthesis | Leave a Comment »

Chromodorolide B synthesis

Posted by naturalproductman on February 24, 2016

Larry Overman and co-workers reported in JACS on the synthesis of chromodorolide B.

JACS paper

Posted in Total Synthesis, Triterpenoids | 2 Comments »

Alstoscholarisine A synthesis

Posted by naturalproductman on February 24, 2016

Yu-Rong Yang and co-workers from the Chinese Academy of Sciences have reported in JACS on the synthesis of (−)-alstoscholarisine A.

 

JACS paper

Posted in Alkaloids, Total Synthesis | Leave a Comment »

α-Aminations via Nitrenoids

Posted by naturalproductman on February 24, 2016

Takashi Ohshima and co-workers from Kyushu University reported in JACS on the use of hypervalent iodine to perform an N-H insertion

 

 

JACS paper

Posted in C-H activation, Hypervalent Iodine, Methodology, Nitrene | Leave a Comment »

Trioxacarcins syntheses

Posted by naturalproductman on February 24, 2016

KC Nicolaou and co-workers reported in JACS on the synthesis of trioxacarcins. The abstract figure looks interstellar.

 

JACS paper

 

 

Posted in Polyketides, Total Synthesis | Leave a Comment »

Some benzyne chemistry

Posted by naturalproductman on February 16, 2016

Michael Greaney and co-workers from the University of Manchester have reported in ACIE on an aryl Truce-Smiles rearrangement to synthesize biaryl amines.

benzyne.gif

ACIE paper

Posted in benzyne, Cascade Reactions, Methodology, Named Reactions, Truce-Smiles rearrangement | Leave a Comment »

[2+2+2] towards rubriflordilactone B

Posted by naturalproductman on February 16, 2016

Zhixiang Xie and co-workers from Lanzhou University have reported in Organic Letters on an approach towards rubriflordilactone B using Wilkinson’s catalyst.

lactone

OL paper

Posted in Cascade Reactions, Lactones, Named Reactions, Total Synthesis | Leave a Comment »

Prostaglandin E2 methyl ester synthesis

Posted by naturalproductman on February 15, 2016

Minoru Isobe and co-workers from National Tsing Hua University have reported in JOC on a synthesis of PGE2 methyl ester using a very nice cascade cyclization.

PGE methyl ester Isobe JOC

 

JOC paper

Posted in Cascade Reactions, Prostaglandins, Total Synthesis | Leave a Comment »

Asymmetric copper catalyzed C-N coupling

Posted by naturalproductman on February 12, 2016

Greg Fu and Jonas Peters and co-workers at Caltech have reported in Science on a copper catalyzed asymmetric C-N bond coupling reaction that required blue light.

 

Science paper

Posted in Asymmetric, Copper, cross coupling, Methodology | Leave a Comment »