Logic behind optimizing

Matthew Sigman and colleague have reported in Science on a way to optimize ligands when searching for a highly enantioselective reaction.  This paper makes me think of when I had an experience in a reaction yielding bad enantioselectivity (~70% ee) and it was frustrating because I didn’t have the time to screen a bunch of random different catalysts.  This way is a good way to guide one through optimizing a reaction and being able to publish in JACS.

Science paper