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Archive for the ‘Physical Organic’ Category

Logic behind optimizing

Posted by naturalproductman on October 13, 2011

Matthew Sigman and colleague have reported in Science on a way to optimize ligands when searching for a highly enantioselective reaction.  This paper makes me think of when I had an experience in a reaction yielding bad enantioselectivity (~70% ee) and it was frustrating because I didn’t have the time to screen a bunch of random different catalysts.  This way is a good way to guide one through optimizing a reaction and being able to publish in JACS.

Science paper

Posted in Asymmetric, Methodology, Physical Organic | Leave a Comment »