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Archive for the ‘Macrocycles’ Category

Antarlides

Posted by naturalproductman on January 26, 2016

Masaya Imoto and co-workers from Keio University have reported in ACIE on some macrolides that acted as androgen receptor antagonists.

 

ACIE paper

Posted in Cancer, Macrocycles, Macrolides | Leave a Comment »

Mandelalide A synthesis

Posted by naturalproductman on January 18, 2016

Rich Carter and co-workers have reported in JACS on the synthesis of mandelalide.

 

 

JACS paper

Posted in Macrocycles, Macrolides, Total Synthesis | Leave a Comment »

Coibamide A synthesis

Posted by naturalproductman on October 15, 2015

Wu Su and co-workers from the Chinese Academy of Sciences have reported in JACS on the synthesis of coibamide A.

peptide

JACS paper

Posted in Macrocycles, Peptides, Structural Reassignment, Total Synthesis | Leave a Comment »

Mycalolides synthesis

Posted by naturalproductman on October 9, 2015

Hideo Kigoshi and co-workers from the University of Tsukuba have reported in ACIE on the synthesis of mycalolides.

oxazole

ACIE paper

Posted in Macrocycles, Metathesis, Methodology, Oxazoles, Ruthenium, Total Synthesis | Leave a Comment »

Nannocystin A

Posted by naturalproductman on July 17, 2015

Dominic Hoepfner and co-workers from Novartis have reported in ACIE on nannocystin A, which had similar binding properties with didemin B on EF-1alpha (elongation factor 1 inhibitor).

nannocystin A

ACIE paper

Mark Brönstrup and co-workers at Helmholtz Zentrum für Infektionsforschung also reported on the isolation of this small molecule. I wonder if there’s a relationship between the two studies.

ACIE paper

the novartis paper states that their study parallels the work in helmholtz. I guess the two studies just coincidentally resulted in the isolation of the same compound.

Posted in Biosynthesis, Cancer, Chemical Biology, Macrocycles, Macrolides, Peptides | Leave a Comment »

Nanocystin A

Posted by naturalproductman on June 6, 2015

Here’re some macrocycles reported in ACIE.
nanocystin A

ACIE paper

Posted in Antibiotics, Macrocycles | Leave a Comment »

Diazonamide analogs through electrochemistry

Posted by naturalproductman on March 5, 2015

Patrick Harran and co-workers have reported in ACIE on an electrochemical approach to access diazonamide analogs.
diazonamide
ACIE paper

Posted in Electrochemical, Macrocycles, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Brefeldin A synthesis

Posted by naturalproductman on February 22, 2015

Alois Furstner and colleague have reported in ACIE on the synthesis of brefeldin A.

brefeldin A

ACIE paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

Miuraenamide sythesis

Posted by naturalproductman on February 22, 2015

Uli Kazmeier and co-workers at Saarland University have reported in ACIE on the synthesis of miuraenamides.

miuraenamides

ACIE paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

Rakicidin A synthesis

Posted by naturalproductman on October 7, 2014

Yue Chen and co-workers from Nankai University have reported in JACS on the synthesis of rakicidin A, which has inhibitory activity towards cancer stem cells.

 

 

JACS paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

 
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