Naturalproductman’s Blog

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Archive for the ‘Macrocycles’ Category

Nannocystin A

Posted by naturalproductman on July 17, 2015

Dominic Hoepfner and co-workers from Novartis have reported in ACIE on nannocystin A, which had similar binding properties with didemin B on EF-1alpha (elongation factor 1 inhibitor).

nannocystin A

ACIE paper

Mark Brönstrup and co-workers at Helmholtz Zentrum für Infektionsforschung also reported on the isolation of this small molecule. I wonder if there’s a relationship between the two studies.

ACIE paper

the novartis paper states that their study parallels the work in helmholtz. I guess the two studies just coincidentally resulted in the isolation of the same compound.

Posted in Biosynthesis, Cancer, Chemical Biology, Macrocycles, Macrolides, Peptides | Leave a Comment »

Nanocystin A

Posted by naturalproductman on June 6, 2015

Here’re some macrocycles reported in ACIE.
nanocystin A

ACIE paper

Posted in Antibiotics, Macrocycles | Leave a Comment »

Diazonamide analogs through electrochemistry

Posted by naturalproductman on March 5, 2015

Patrick Harran and co-workers have reported in ACIE on an electrochemical approach to access diazonamide analogs.
diazonamide
ACIE paper

Posted in Electrochemical, Macrocycles, Methodology, Oxazoles, Total Synthesis | Leave a Comment »

Brefeldin A synthesis

Posted by naturalproductman on February 22, 2015

Alois Furstner and colleague have reported in ACIE on the synthesis of brefeldin A.

brefeldin A

ACIE paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

Miuraenamide sythesis

Posted by naturalproductman on February 22, 2015

Uli Kazmeier and co-workers at Saarland University have reported in ACIE on the synthesis of miuraenamides.

miuraenamides

ACIE paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

Rakicidin A synthesis

Posted by naturalproductman on October 7, 2014

Yue Chen and co-workers from Nankai University have reported in JACS on the synthesis of rakicidin A, which has inhibitory activity towards cancer stem cells.

 

 

JACS paper

Posted in Macrocycles, Total Synthesis | Leave a Comment »

Belizentrin synthesis

Posted by naturalproductman on August 18, 2014

Hernandez Daranas and co-workrs from the University of La Laguna in Spain have reported in Organic Letters on the isolation of belizentrin.

belizentrin

OL paper

Posted in Macrocycles | Leave a Comment »

Sarcophytonolide synthesis

Posted by naturalproductman on February 20, 2013

Isao Kadota and co-workers from Okayama University have reported in Org Lett on a synthesis of sarcophytonolide.

diastereomers

OL paper

Posted in Macrocycles, Methodology | Leave a Comment »

Selective macrocyclization

Posted by naturalproductman on April 23, 2012

Christopher Boddy and co-workers at the University of Ottawa have reported in Organic Letters on the selective macrocyclization using DEBS TE.

enzyme

OL paper

Posted in Chemical Biology, Enzymatic, Macrocycles, Macrolides, Methodology | Leave a Comment »

Roseophilin synthesis

Posted by naturalproductman on March 29, 2012

Bernard Flynn and colleague at Monash University in Australia have reported in Organic Letters on a novel approach to roseophilin.
roseophilin

OL paper

Posted in Alkaloids, Macrocycles, Methodology | Leave a Comment »

 
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