Mechanistic studies of cascade Schmidt reaction

Jeffrey Aube and co-workers at the University of Kansas have reported in JACS on their mechanistic studies of a cascade intramolecular Schmidt reaction.

JACS paper

Stemonamide Synthesis

Fu-Min Zhang and co-workers at Lanzhou University have published in Chem Comm on a synthesis of stemonamide where a Schmidt reaction was used to access the 5,7-A,B-ring system.

Chem Comm paper

Prins-Schmidt Cascade

Jeffrey Aube and co-workers from the University of Kansas have recently published in Organic Letters on a tandem Prins/Schmidt reaction mediated by titanium tetrachloride to access the a 5,6,6-tricyclic ring system belonging to some alkaloids – cyclindricine and lepadiformine (diastereomers).

OL paper

Intramolecular Schmidt on Azido Acetal

Jeffrey Aube and co-worker at the University of Kansas have recently published in JACS on the intramolecular Schmidt reaction using an acetal instead of the unprotected ketone to control the regioselectivity.

JACS paper