Towards halichondrins

I would call the vinyl halide coupling reaction with an aldehyde using chromium/nickel combination a Nozaki Hiyama Kishi coupling, but maybe because the author is one of the people in the named reaction, it wasn’t mentioned in the paper as the “NHK reaction”, but rather, a Ni/Cr-mediated reaction.

JACS paper

JACS paper 2

Juglomycin A synthesis

Rodney Fernandes and co-workers from IIT Bombay have reported in JOC on a chromium carbene approach to access juglomycin.

JOC paper

Chromium cascade

Nobuhara Iwasawa and co-workers at Tokyo Institute of Technology have reported in ACIE on a chromium catalyzed cascade.

ACIE paper

Abyssomicin synthesis

Radomir Saicic and colleague at the University of Belgrade in Serbia have reported in ACIE on the synthesis of atrop-abyssomicin.

ACIE paper

NHK coupling asymmetrically

The Nozaki-Hiyama-Kishi coupling couples an a R-halide group with an aldehyde.  Kishi and co-workers have reported on a catalytic, asymmetric version in JACS recently.

JACS paper

2 Rings in One Step

James Herndon and co-workers from New Mexico State University have reported in Organic Letters on the synthesis of benzocycloheptanones from a chromium carbene substrate.

OL paper

Chromium Carbene Cascade

Binay Ghorai and co-worker from Bengal Engineering and Science University have published in Tetrahedron Letters on a Fischer carbene approach to access furoquinolines.

TL paper

Multicomponent Coupling [2+2+1+1]

Jose Barluenga and co-workers from the Universidad de Oviedo have published in ACIEE on a multicomponent approach to access hydroxycyclohexenones.

 

ACIEE paper

Rhodium Catalyzed [3+2+2]

Jose Barluenga and co-workers at the Universidad de Oviedo have published in Tetrahedron on the use of Fischer carbenes to employ a [3+2+2] cycloaddition in order to access seven membered rings.

Tetrahedron paper

Polycyclizations

James Herndon and co-workers from New Mexico State University have published in Tetrahedron Letters on a coupling between an enyne-aldehyde and a Fischer carbene, which results in multiple cyclization events when the temperature is elevated.

TL paper