Some benzyne chemistry

Michael Greaney and co-workers from the University of Manchester have reported in ACIE on an aryl Truce-Smiles rearrangement to synthesize biaryl amines.

ACIE paper

Benzyne chemistry for tubingensin A

Neil Garg and co-workers have reported in JACS on the synthesis of tubingensin A. An interesting [2+2] reaction occurred between a benzyne and an enolate.

JACS paper

First benzynes now pyridynes

Benzynes have been the rage lately but I guess it was bound to happen where someone would exploit pyridynes.

 

OL paper

Benzyne cascade

Richard Hsung and co-workers at the University of Wisconsin have reported in Organic Letters on a synthesis of chelidonine.

OL paper

MCC with benzynes

Hiroto Yoshida and co-workers at Hiroshima University have reported in ACIEE on a three component coupling between a benzyne, aryl or alkynyl bromide and nucleophile to form substituted aryl bromides.  What’s fascinating is that the aryl or alkynyl group transfers to the nucleophile.

ACIEE paper

Benzynes with allenoic acids

Shengming Ma and co-workers at Zhejiang University have reported on the utility of allenoic acids by reacting them with benzynes to form chromones.

OL paper

Benzyne mcr

Hideto Miyabe and co-workers from Hyogo University have reported in ACIEE on a multicomponent reaction between benzynes, DMF and beta-ketoesters or 1,3-diketones to afford 2H-chromene or isocoumarin derivatives.

ACIEE paper