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Archive for the ‘[2+2]’ Category

[2+2] stereochemistry

Posted by naturalproductman on April 12, 2015

Thorsten Bach and co-workers at Technische Universität München have reported in JACS on the stereochemistry of some [2+2] reactions.

2+2
JACS paper

Posted in Light Mediated, Methodology, [2+2] | Leave a Comment »

[2+2] via oxazaborolidine

Posted by naturalproductman on March 22, 2015

M. Kevin Brown and co-workers at Indiana University have reported in JACS on an asymmetric [2+2] using an oxazaborolidine catalyst.

2+2

JACS paper

Posted in Asymmetric, Cycloaddition, Methodology, [2+2] | Leave a Comment »

Strained alkynes are in

Posted by naturalproductman on October 25, 2014

Rick Danheiser and colleague have reported in JACS on the synthesis of an aza-cyclohexyne to do the chemistries that other people have been doing with benzynes.

alkyne

JACS paper

Posted in Diels-Alder, Methodology, Named Reactions, [2+2] | Leave a Comment »

Dictazole synthesis

Posted by naturalproductman on May 13, 2014

Grey Erwan Poupon and co-workers at CNRS have reported in ACIE on the synthesis of dictazole.

dictazole

ACIE paper

Posted in Alkaloids, Methodology, Total Synthesis, [2+2] | Leave a Comment »

Asymmetric [2+2]

Posted by naturalproductman on April 25, 2014

Tehshik Yoon and co-workers published in Science on an enantioselective [2+2] reaction.

Science paper

Posted in Asymmetric, Cycloaddition, Light Mediated, Methodology, Pericyclic reactions, [2+2] | Leave a Comment »

Asymmetric [2+2]

Posted by naturalproductman on November 15, 2013

Thorsten Bach and colleague have reported in Science on a Lewis acid catalyzed [2+2] reaction.

 

Science paper

Posted in Asymmetric, Cascade Reactions, Cycloaddition, Methodology, Pericyclic reactions, [2+2] | 1 Comment »

Gold catalyzed [2+2]

Posted by naturalproductman on March 20, 2013

Antonio Echavarren and co-workers from ICIQ in Spain have reported in Org Lett on a gold catalyzed intramolecular [2+2] between an alkene and alkyne.

[2+2]

OL paper

Posted in Cycloaddition, Gold, Methodology, Pericyclic reactions, Transition Metal, [2+2] | Leave a Comment »

That’s pretty strained

Posted by naturalproductman on February 20, 2013

Fumitoshi Kakiuchi and co-workers from Keio University have reported in Org Lett on a rhodium catalyzed [2+2] reaction between a terminal alkyne and an electron deficient alkene to form a cyclobutene.

strained

OL paper

Posted in Cycloaddition, Methodology, Rhodium, Transition Metal, [2+2] | Leave a Comment »

[2+2] by cationic gold

Posted by naturalproductman on October 17, 2012

Jose Gonzalez and co-workers from the University of Oviedo have reported in ACIE on a cationic gold catalyzed [2+2] reaction.

2+2

ACIE paper

Posted in Gold, Methodology, Transition Metal, [2+2] | Leave a Comment »

Jiadifenin synthesis

Posted by naturalproductman on August 29, 2012

Hongbin Zhai and co-workers at SIOC have reported in ACIE on the synthesis of jiadifenin.  The key [2+2] installed the methyl ester substituent.

jiadifenin synthesis

ACIE paper

Posted in Allenes, Cycloaddition, Methodology, Pericyclic reactions, Total Synthesis, [2+2] | Leave a Comment »

 
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