Michael followed by Pictet-Spengler

Xiaoyu Wu and co-workers at Shanghai University have reported in Chemistry a European Journal on a reaction that involves two named reaction using an indole tethered with a primary amine and an alkynoate as the subtrates.

Chemistry a European Journal paper

Arizonin C1 synthesis

Reinhard Bruckner and co-workers at Universitat Freiburg have reported in the European JOC on their synthesis of arizonin C1.

European JOC paper

Tadalafil Analogs

Benoit Deprez and co-workers at Universite Lille Nord de France have reported in the Journal of Medicinal Chemistry on the synthesis and activity relationships of tadalafil.

JMC paper

Alstoscholarine Syntheses

Jieping Zhu and co-workers at CNRS have reported in ACIEE on a synthesis of alstoscholarine – what a scholarly piece of work.

ACIEE paper

Phalarine Synthesis

Samuel Danishefsky and co-workers have published in JACS on the total synthesis of phalarine from an amino acid.

JACS paper

Michael Addition followed by Pictet-Spengler

Gang Zhao and co-workers from the Shanghai Institute of Organic Chemistry have recently published in Chemical Communications on a one pot three component coupling process that involves a Michael addition followed by a Pictet Spengler reaction.

Chemical Communications paper

Tangutorine Synthesis

Here’s a nice alkaloid total synthesis by Yasumasa Hamada and co-workers at Chiba University.

OL paper