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Archive for the ‘Rhodium’ Category

Alkyne hydrothiolation with Wilkinson’s catalyst

Posted by naturalproductman on January 27, 2016

Jennifer Love and co-workers from the University of British Columbia reported in Organic Letters on the use of Wilkinson’s catalyst to perform a hydrothiolation reaction across an alkyne to synthesize K777, a cysteine protease inhibitor.

 

OL paper

Posted in Methodology, Rhodium, Transition Metal | Leave a Comment »

An allene and cyclobutanone walk into a bar…

Posted by naturalproductman on October 21, 2015

Guangbin Dong and colleague have reported in JACS on an intramolecular coupling between cyclobutanones and allenes.

cyclobutanone

JACS paper

Posted in Cascade Reactions, Methodology, Rhodium, Ring forming, Ring Opening, Transition Metal | Leave a Comment »

ent-Ketorfanol synthesis

Posted by naturalproductman on August 18, 2015

Jonathan Ellman and co-workers have reported in ACIE on the synthesis of ent-ketorfanol.

alkaloid

ACIE paper

Posted in Alkaloids, Rhodium, Total Synthesis, Transition Metal | Leave a Comment »

Brevisin via epoxide ring opening

Posted by naturalproductman on May 28, 2015

Timothy Jamison and co-workers have reported in JACS on their formal synthesis of brevisin.

polyepoxide

JACS paper

Posted in Cascade Reactions, Formal Synthesis, Rhodium, Total Synthesis, Transition Metal | Leave a Comment »

A Formal Metathesis

Posted by naturalproductman on April 16, 2015

Zhang Jie-Shi and co-workers from the Chinese Academy of Sciences have reported in JACS on a rhodium catalyzed exchange between an aryl keton and an aryl carboxylic acid to form aliphatic carboxylic acids and biaryl compounds.

cascade

JACS paper

Posted in Cascade Reactions, Metathesis, Methodology, Rhodium, Transition Metal | Leave a Comment »

Arylnitrones to indolynes

Posted by naturalproductman on April 12, 2015

Sukbok Chang and colleague at KAIST have reported in JACS on a synthesis of indolynes using a rhodium catalyst.

indolyne

JACS paper

Posted in Cascade Reactions, Methodology, Rhodium, Transition Metal | Leave a Comment »

B-H Functionalization

Posted by naturalproductman on April 12, 2015

Ming-Hua Xu and co-workers from the Chinese Academy of Sciences have reported in JACS on a rhodium catalyzed carbene insertion into a B-H bond.

B-H

JACS paper

Posted in Carbene, Methodology, Rhodium, Transition Metal | Leave a Comment »

Rh-catalyzed cascade

Posted by naturalproductman on March 5, 2015

P. Andrew Evans and co-workers at Queen’s University have reported in ACIE on a rhodium catalyzed [(3+2)+2] carbocyclization.

rhodium

ACIE paper

Posted in Cascade Reactions, Methodology, Rhodium, Transition Metal | Leave a Comment »

B-H insertions

Posted by naturalproductman on March 5, 2015

Ming-Hua Xu and co-workers from the Chinese Academy of Sciences have reported in JACS on a rhodium catalyzed transformation of a diazo to an organoborane.

B-H

JACS paper

Posted in Carbene, Cascade Reactions, Methodology, Rhodium, Transition Metal | Leave a Comment »

Rh-catalyzed arylation

Posted by naturalproductman on March 5, 2015

Tamio Hayashi and colleague at the National University of Singapore have reported in JACS on a rhodium catalyzed asymmetric arylation of an alkenyl sulfone.

rhodium

JACS paper

Posted in Asymmetric, Methodology, Rhodium, Total Synthesis, Transition Metal | Leave a Comment »

 
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