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Archive for the ‘Organocatalytic’ Category

Chiral phosphoric acid for allenamides with ketones

Posted by naturalproductman on January 29, 2016

Dean Toste and colleague have reported in Chemical Science on the use of a chiral phosphoric acid catalyst to react allenamides with ketones. I guess the papers published in Chemical Science in 2015 and 2016 are all open access.

 

Chemical Science paper

Posted in Allenes, Methodology, Organocatalytic | Leave a Comment »

Back to Back Method Papers: Allenamide + Aldehyde = alpha-Alkylation

Posted by naturalproductman on January 22, 2016

Fernando Lopez and co-workers at Universidad de Santiago de Compostela have reported in Chemical Communications on a gold/organocatalyst-cocatalyzed alpha alkylation of aldehydes. Interestingly Jose Gonzalez and co-workers at Universidad de Oviedo also reported in Chem Comm on a gold/organocatalyst reaction.

 

Chem Comm paper

 

Chem Comm paper 2

Posted in Allenes, Asymmetric, Cascade Reactions, Cooperative Catalysis, Gold, Methodology, Organocatalytic, Transition Metal | Leave a Comment »

Hetero-Diels-Alder/Oxy-Michael cascade

Posted by naturalproductman on January 22, 2016

John Gao and co-workers from UT San Antonio have reported in ACIE on the use of modularly designed organocatalysts (MDO) to effect a hetero-Diels-Alder/oxy-Michael cascade reaction.

 

ACIE paper

Posted in Cascade Reactions, Diels-Alder, Kinetic resolution, Methodology, Named Reactions, Organocatalytic, Oxy-Michael | Leave a Comment »

Cascade cyclization

Posted by naturalproductman on November 10, 2015

Hiroaki Sasai and co-workers at Osaka University have reported in ACIE on a domino reaction involving the coupling between an allenoate ester and dienones.
allenoate

ACIE paper

Posted in Asymmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Asymmetric Passerini reaction

Posted by naturalproductman on November 3, 2015

When I saw the Passerini reaction in the title, I thought of the use of an Ugi reaction in the synthesis of dysibetaine by the Kobayashi group. Bin Tan and co-workers at South University of Science and Technology in China have reported in JACS on a phosphoric acid catalyzed Passerini reaction.

Passerini

JACS paper

Posted in Asymmetric, Methodology, Multi-Component Coupling, Organocatalytic | Leave a Comment »

Enantioselective Intermolecular Cross-Rauhut–Currier

Posted by naturalproductman on November 3, 2015

Junliang Zhang and co-workers from East China Normal University have reported in ACIE on an asymmetric Cross-Rauhut-Currier reaction.

coupling

ACIE paper

Posted in Asymmetric, Methodology, Named Reactions, Organocatalytic | Leave a Comment »

Asymmetric spiroketalization

Posted by naturalproductman on October 29, 2015

Seijiro Matsubara and co-workers at Kyoto University have reported in ACIE on the use of an aminothiourea catalyst to form spiroketals asymmetrically.

amino

ACIE paper

Posted in Asymmetric, Methodology, Organocatalytic, Spirocycles | Leave a Comment »

Sulfenate catalyzed alkynylation

Posted by naturalproductman on August 7, 2015

Patrick Walsh and co-workers have reported in JACS on a new way to organocatalytically make alkynes using a sulfenate anion.
organocatalytic
JACS paper

Posted in Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Pyridinium catalyzed glycosylation

Posted by naturalproductman on July 17, 2015

Albrecht Berkessel and co-workers at Cologne University have reported in ACIE on a pyridinium catalyzed glycosylation reaction.
pyridinium
ACIE paper

Posted in Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Nazarov-semipinacol cascade

Posted by naturalproductman on July 11, 2015

Take a cyclobutanol bearing dienone and see what kind of Nazarov reaction occurs…Yong-Qiang Tu and co-workers at Lanzhou University reported in JACS on this interesting asymmetric transformation.

Nazarov

JACS paper

Posted in Asymmetric, Cascade Reactions, Methodology, Named Reactions, Nazarov cyclization, Organocatalytic | Leave a Comment »

 
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