Naturalproductman’s Blog

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Archive for the ‘Organocatalytic’ Category

A3 reaction with thiourea cocatalyst

Posted by naturalproductman on April 12, 2015

Daniel Seidel and co-worker at Rutgers have reported in JACS on an asymmetric A3 reaction using a thiourea cocatalyst.

A3

JACS paper

Posted in Cascade Reactions, Copper, Methodology, Multi-Component Coupling, Organocatalytic, Transition Metal | Leave a Comment »

Phosphoric acid catalyzed alpha-amination

Posted by naturalproductman on March 5, 2015

Dean Toste and colleague have reported in JACS on a phosphoric acid catalyzed alpha-amination of ketones – I am reminded of Hisashi Yamamoto’s silver BINAP methodology back in 2003.

phosphoric acid

JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Organocatalytic epoxidation

Posted by naturalproductman on August 31, 2014

Philip Bulman Page and co-workers at the University of East Anglia have reported in Tetrahedron on an iminium catalyzed epoxidation.
epoxidation

Tetrahedron paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Bislactone desymmetrization

Posted by naturalproductman on July 27, 2014

Jieping Zhu and co-workers have reported in ACIE on the synthesis of rhazinilam and leucomidine B.

desymmetrize

ACIE paper

Posted in Alkaloids, Asymmetric, C2-Symmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Carboboration, organocatalytically

Posted by naturalproductman on July 27, 2014

Masaya Sawamura and co-workers at Hokkaido University have reported in JACS on a carboboration of alkynoates.

carboboration

JACS paper

Posted in Conjugate Additions, Methodology, Organocatalytic | Leave a Comment »

Minovincine synthesis

Posted by naturalproductman on September 5, 2013

David Macmillan and co-workers have reported in ACIE on a synthesis of minovincine.

minovicine

ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Organocatalytic, Total Synthesis | Leave a Comment »

(−)-Aspidospermidine, (−)-Tabersonine, and (−)-Vincadifformine syntheses

Posted by naturalproductman on August 30, 2013

Rodrigo Andrade and colleague at Temple University have reported in JACS on a cascade synthesis of some aspidosperma alkaloids.

aspidosperma

JACS paper

Posted in Alkaloids, Cascade Reactions, Methodology, Organocatalytic, Total Synthesis | Leave a Comment »

KR by NHC

Posted by naturalproductman on July 24, 2013

Kenichi Yamada and co-workers at Kyoto University have reported in JACS on a kinetic resolution approach to resolve 1,2-diols.
NHC

JACS paper

Posted in Asymmetric, Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

Diyne desymmetrization

Posted by naturalproductman on May 21, 2013

Ulrich Hennecke and co-workers at the Universitat Munster have reported in JAC on a desymmetrization of a diyne.

Diyne

JACS paper

Posted in Alkaloids, Asymmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Cinchona alkaloid catalyzed proton transfer

Posted by naturalproductman on May 14, 2013

Jin-Pei Cheng and co-workers from Nankai University have reported in JACS on a biomimetic proton transfer.

biomimetic

JACS paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

 
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