Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Organocatalytic’ Category

Desymmetrization with proline and Pd

Posted by naturalproductman on April 19, 2016

Yi-Xia Jia and co-workers from Zhejiang University have reported in JACS on an intramolecular desymmetrization by a Heck reaction.

 

JACS paper

Posted in Desymmetrization, Heck, Methodology, Mizoroki-Heck, Organocatalytic, Palladium, Transition Metal | Leave a Comment »

Epoxide to Thiiranes

Posted by naturalproductman on April 14, 2016

Benjamin List and co-workers reported in JACS on a kinetic resolution approach to convert epoxides to thiiranes using a chiral phosphoric acid catalyst.

 

JACS paper

Posted in Kinetic resolution, Methodology, Organocatalytic | Leave a Comment »

Haliclonin A synthesis

Posted by naturalproductman on February 24, 2016

Pei-Qiang Huang and co-workers from Xiamen University have reported in ACIE on the synthesis of haliclonin A.

 

ACIE paper

Posted in Alkaloids, Methodology, Organocatalytic, Total Synthesis | Leave a Comment »

Chiral phosphoric acid for allenamides with ketones

Posted by naturalproductman on January 29, 2016

Dean Toste and colleague have reported in Chemical Science on the use of a chiral phosphoric acid catalyst to react allenamides with ketones. I guess the papers published in Chemical Science in 2015 and 2016 are all open access.

 

Chemical Science paper

Posted in Allenes, Methodology, Organocatalytic | Leave a Comment »

Back to Back Method Papers: Allenamide + Aldehyde = alpha-Alkylation

Posted by naturalproductman on January 22, 2016

Fernando Lopez and co-workers at Universidad de Santiago de Compostela have reported in Chemical Communications on a gold/organocatalyst-cocatalyzed alpha alkylation of aldehydes. Interestingly Jose Gonzalez and co-workers at Universidad de Oviedo also reported in Chem Comm on a gold/organocatalyst reaction.

 

Chem Comm paper

 

Chem Comm paper 2

Posted in Allenes, Asymmetric, Cascade Reactions, Cooperative Catalysis, Gold, Methodology, Organocatalytic, Transition Metal | Leave a Comment »

Hetero-Diels-Alder/Oxy-Michael cascade

Posted by naturalproductman on January 22, 2016

John Gao and co-workers from UT San Antonio have reported in ACIE on the use of modularly designed organocatalysts (MDO) to effect a hetero-Diels-Alder/oxy-Michael cascade reaction.

 

ACIE paper

Posted in Cascade Reactions, Diels-Alder, Kinetic resolution, Methodology, Named Reactions, Organocatalytic, Oxy-Michael | Leave a Comment »

Cascade cyclization

Posted by naturalproductman on November 10, 2015

Hiroaki Sasai and co-workers at Osaka University have reported in ACIE on a domino reaction involving the coupling between an allenoate ester and dienones.
allenoate

ACIE paper

Posted in Asymmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Asymmetric Passerini reaction

Posted by naturalproductman on November 3, 2015

When I saw the Passerini reaction in the title, I thought of the use of an Ugi reaction in the synthesis of dysibetaine by the Kobayashi group. Bin Tan and co-workers at South University of Science and Technology in China have reported in JACS on a phosphoric acid catalyzed Passerini reaction.

Passerini

JACS paper

Posted in Asymmetric, Methodology, Multi-Component Coupling, Organocatalytic | Leave a Comment »

Enantioselective Intermolecular Cross-Rauhut–Currier

Posted by naturalproductman on November 3, 2015

Junliang Zhang and co-workers from East China Normal University have reported in ACIE on an asymmetric Cross-Rauhut-Currier reaction.

coupling

ACIE paper

Posted in Asymmetric, Methodology, Named Reactions, Organocatalytic | Leave a Comment »

Asymmetric spiroketalization

Posted by naturalproductman on October 29, 2015

Seijiro Matsubara and co-workers at Kyoto University have reported in ACIE on the use of an aminothiourea catalyst to form spiroketals asymmetrically.

amino

ACIE paper

Posted in Asymmetric, Methodology, Organocatalytic, Spirocycles | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 83 other followers