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Archive for the ‘Cascade Reactions’ Category

multiple reactions back to back (to back) in one go

Bicyclomycin formal synthesis

Posted by naturalproductman on August 26, 2015

Ullrich Jahn and co-workers from the Academy of the Sciences of the Czech Republic reported in ACIE on a formal synthesis of bicyclomycin.
radical
ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

Nitrosostyrenes to indoles

Posted by naturalproductman on August 19, 2015

Jieping Zhu and co-workers have reported in ACIE on a titanium trichloride mediated cyclization-reduction of nitrosostyrenes to indoles.
nitrosostyrene

ACIE paper

Posted in Cascade Reactions, Indoles, Methodology, Titanium, Transition Metal | Leave a Comment »

Cyclopropenones – a chemical biology tool

Posted by naturalproductman on August 7, 2015

Jennifer Prescher and colleague at UC Irvine have reported in JACS on the potential for using cyclopropenones to conjugate proteins.

amine

JACS paper

Posted in Cascade Reactions, Chemical Biology, New Setups | Leave a Comment »

Sulfenate catalyzed alkynylation

Posted by naturalproductman on August 7, 2015

Patrick Walsh and co-workers have reported in JACS on a new way to organocatalytically make alkynes using a sulfenate anion.
organocatalytic
JACS paper

Posted in Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Chlorinated tetrahydropyran opening

Posted by naturalproductman on August 5, 2015

Elizabeth Jarvo and co-workers at UC Irvine have reported in JACS on a cyclopropane ring formation from a chlorinated tetrahydropyran.

THP

JACS paper

Posted in Cascade Reactions, Methodology, Ring forming | Leave a Comment »

Ni-catalyzed cyclopropanation

Posted by naturalproductman on July 30, 2015

Peter Chen and co-workers from ETH Zurich have reported in ACIE on a nickel catalyzed cyclopropanation. Looks similar to a Corey-Chaykovsky cyclopropanation because of the formation of an ylide.

nickel

ACIE paper

Posted in Carbene, Cascade Reactions, Methodology, Nickel, Transition Metal | Leave a Comment »

Hydroamidocarbonylation

Posted by naturalproductman on July 30, 2015

Matthias Keller and co-workers have reported in ACIE on a hydroamidocarbonylation of olefins.
hydroamidocarbonylation

ACIE paper

Posted in Cascade Reactions, Methodology, Palladium, Transition Metal | Leave a Comment »

Cannizzaro cascade

Posted by naturalproductman on July 30, 2015

Simon Woodward and co-workers have reported in ACIE on a Cannizzaro cascade reaction using tert-butyl lithium.
cascade
ACIE paper

Posted in Cascade Reactions, Methodology, Multi-Component Coupling | Leave a Comment »

4pi-Electrocyclic ring opening cascade

Posted by naturalproductman on July 23, 2015

Kiyosei Takasu and co-workers from Kyoto University have reported in JACS on a ring expansion cross coupling cascade.

JACS paper

Posted in Cascade Reactions, Electrocyclization, Methodology, Palladium, Transition Metal | Leave a Comment »

Hosieine A synthesis

Posted by naturalproductman on July 22, 2015

Ran Hong and co-workers at SIOC have reported in ACIE on the synthesis of hosieine A. The pyridone moiety reminds of lyconadin.

alkaloid

ACIE paper

Posted in Alkaloids, Cascade Reactions, Methodology, Total Synthesis | Leave a Comment »

 
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