Naturalproductman’s Blog

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Archive for the ‘renal’ Category

Chlorinated englerins

Posted by naturalproductman on February 10, 2012

John Beutler and co-workers from the NCI have reported in the Journal of Natural Products on the isolation of chlorinated englerins and their anti-cancer activities.


JNP paper

Posted in Cancer, renal, Sesquiterpenes, Sesquiterpenoids | Leave a Comment »


Posted by naturalproductman on January 12, 2011

Christian Hertweck and co-workersfrom HKI in Germany have published in ACIEE on the isolation of a group of macrolides and divergolide D was the most cytotoxic with IC50 values ranging from 1-2 micromolar against lung cancer (LXFA 629L), pancreatic cancer (PANC-1), renal cancer (RXF 486L), and sarcoma (Saos-2) cancer cell lines.


ACIEE paper

Posted in Cancer, lung, Macrolides, Polyketides, renal | 1 Comment »


Posted by naturalproductman on March 19, 2010

Jung-Rae Rho and co-workers from Kunsan have recently isolated gukulenins A and B from the Korean marine sponge Phorbas gukulensis.  The tetraterpenoid gukulenin A had a cytotoxic IC50 value of 57 nM against FaDu human pharynx cancer cell lines.


JNP paper

Posted in Cancer, colon, pharynx, renal, stomach, Terpenoids | Leave a Comment »