Colletoic acid synthesis

Masahisa Nakada and co-worker from Waseda University have reported in Org Lett on a synthesis of colletoic acid.

OL paper

Psoromic acid inhibits RabGGTase

Yao-Wen Wu and co-workers at Max Planck have reported in JACS on the inhibition of RabGGTase using psoromic acid.

JACS paper

Diepoxide intermediate

Hideaki Oikawa and co-workers at Hokkaido University have reported in JACS on a sequential epoxidation of a bis olefin compound to yield a diepoxide that undergoes a ring opening cascade to form two cyclic polyethers (a tetrahydropyran and tetrahydrofuran).

JACS paper

Bexarotene and Alzheimer’s

Many people have probably already heard of this report in Science of an anti-cancer drug, bexarotene, being effective against treating Alzheimer’s disease.

 

Science paper

Arundic acid synthesis

Rodney Fernandes and co-workers from IIT Bombay have reported in European JOC on the synthesis of arundic acid.

European JOC paper

Trachyspic acid via MCC

Jeffrey Johnson and co-workers at UNC have reported in Organic Letters on their multi-component coupling reaction to access the carbon backbone of trachyspic acid.

OL paper