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Archive for the ‘C-H activation’ Category

First paper published

Posted by naturalproductman on November 6, 2017

Francis Yoshimoto and co-workers at the University of Texas at San Antonio report in the journal, Steroids, on the synthesis of a neurosteroid produced in the brains, 7alpha-hydroxypregnenolone, through an allylic C7-oxidation reaction. The oxidation was performed through either a C7-oxidation through CrO3 in the presence of 3,5-dimethylpyrazole followed by a stereoselective reduction or a regioselective and stereoselective allylic benzoyloxylation using CuBr and tert-butylperoxy benzoate.

STEROIDS FKY

Steroids paper

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Posted in C-H activation, Stereochemistry, Steroids, Total Synthesis | Leave a Comment »

C-H Allylation

Posted by naturalproductman on September 7, 2016

Hon-Wai Lam and co-workers from the University of Nottingham have reported in JACS on a rhodium catalyzed C-H allylation process.

 

JACS paper

Posted in C-H activation, Rhodium | Leave a Comment »

Triiodide-mediated C-H amination

Posted by naturalproductman on July 31, 2016

David Nagib and co-workers from the Ohio State University have reported in ACIE on a triiodide mediated C-H amination reaction.

 

ACIE paper

Posted in C-H activation, Hypervalent Iodine, Methodology | Leave a Comment »

Towards indoxamycin via C-H functionalization

Posted by naturalproductman on May 29, 2016

Erik Sorensen and Huw Davies and co-workers reported in ACIE on a C-H functionalization approach towards indoxamycin.

 

ACIE paper

Posted in C-H activation, Cascade Reactions, Methodology | Leave a Comment »

C-H silylation

Posted by naturalproductman on April 6, 2016

L.T. Pilarski and co-workers from the University of Uppsala in Sweden have reported in Chemical Communications on a ruthenium catalyzed C-H silylation.

 

Chem Comm paper

Posted in C-H activation, Methodology, Ruthenium, Transition Metal | Leave a Comment »

Looks like a ring-closing metathesis

Posted by naturalproductman on March 9, 2016

At first I thought this was a ring closing metathesis reaction  but the catalyst was rhodium and there is an extra allylic methyl group – it is a cycloisomerization reaction (by Vy Dong’s group).

 

 

JACS paper

Posted in Asymmetric, C-H activation, Methodology, Rhodium, Transition Metal | Leave a Comment »

α-Aminations via Nitrenoids

Posted by naturalproductman on February 24, 2016

Takashi Ohshima and co-workers from Kyushu University reported in JACS on the use of hypervalent iodine to perform an N-H insertion

 

 

JACS paper

Posted in C-H activation, Hypervalent Iodine, Methodology, Nitrene | Leave a Comment »

Light + N-Chloroamides = C-H Chlorination

Posted by naturalproductman on January 18, 2016

Erik Alexanian and Chris Vanderwal groups teamed up to publish this C-H chlorination reaction in JACS.

 

JACS paper

Posted in C-H activation, Methodology, Total Synthesis | Leave a Comment »

Steroid C12-hydroxylation published in JACS

Posted by naturalproductman on October 22, 2015

Phil Baran and co-workers reported in JACS on a copper catalyzed C12-hydroxylation reaction.
C12
 

 

JACS paper

Posted in C-H activation, Copper, Methodology, Steroids, Transition Metal | Leave a Comment »

C-H oxidation

Posted by naturalproductman on October 7, 2015

Melanie Sanford and colleague have reported in JACS on a Pt-catalyzed terminal C-H oxidation of aliphatic amines.

C-H

JACS paper

Posted in C-H activation, Copper, Methodology, Platinum, Transition Metal | Leave a Comment »