Naturalproductman’s Blog

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Archive for the ‘Diseases’ Category

Alpha-bisabolol

Posted by naturalproductman on July 15, 2015

Victoriano Corpas-Lopez and co-workers at Universidad de Granada have reported in Journal of Natural Products on the use of alpha-bisabolol as a treatment for visceral leishmaniasis.

JNP paper

Posted in Diseases | Leave a Comment »

HIV integrase inhibitor synthesis

Posted by naturalproductman on May 12, 2015

Chris Senanayake and co-workers from Boehringer-Ingelheim have reported in ACIE on the synthesis of

HIV

ACIE paper

Posted in Diseases, HIV, Total Synthesis | Leave a Comment »

MAP4K4 for neurodegenerative diseases

Posted by naturalproductman on April 26, 2015

Herbert Waldmann and co-workers at Technische Universität Dortmund have reported in ACIE on MAP4K4 as a target for neurodegenerative diseases.

MAP

ACIE paper

Posted in Diseases, Medicinal Chemistry, Neurodegenerative, Protein Targets, Proteins | Leave a Comment »

Kalihinol B synthesis

Posted by naturalproductman on April 12, 2015

Christopher Vanderwal and co-workers have reported in JACS on the synthesis of kalihinol B.
kalihinol

JACS paper

Posted in Diseases, Malaria, Total Synthesis | Leave a Comment »

Lactate dehydrogenase inhibitors for epilepsy

Posted by naturalproductman on March 21, 2015

Tsuyoshi Inoue and co-workers at Okayama University have reported in Science on lactate dehydrogenase inhibition using stiripentol analogs as a strategy to treat epileptic seizures.

Science paper

Posted in Diseases | Leave a Comment »

Efavirenz flow synthesis

Posted by naturalproductman on March 5, 2015

Peter Seeberger and co-workers at Max Planck Institute of Colloids and Interfaces have reported in ACIE on the flow synthesis of efavirenz.

flow

ACIE paper

Posted in Flow, HIV, New Setups, Total Synthesis | Leave a Comment »

Salinipostins

Posted by naturalproductman on January 18, 2015

Roger Linington and co-workers from UCSC have reported in JOC on the isolation of salinipostins.

salinipostins
JOC paper

Posted in Diseases, Malaria, Phosphates | Leave a Comment »

Myrioneurinol synthesis

Posted by naturalproductman on November 4, 2014

Steven Weinreb and colleague at Penn State have reported in ACIE on the synthesis of myrioneurinol.

alkaloid

ACIE paper

Posted in Diseases, Malaria, Total Synthesis | Leave a Comment »

ZMapp vs. ebola

Posted by naturalproductman on August 30, 2014

Gary Kopinger and co-workers from the University of Manitoba have reported in Nature on ZMapp’s reversion of the ebola virus.
Nature paper

Posted in Anti-viral, Diseases | Leave a Comment »

Aspergillomarasmine A

Posted by naturalproductman on June 28, 2014

Gerald Wright and co-workers from McMaster University in Canada have reported in Nature on aspergillomarasmine A being a good inhibitor for the New Dehli Metallo beta-lactamase 1 (NDM-1) enzyme.

 

Nature paper

Posted in Amino Acids, Antibiotics, Diseases | 1 Comment »

 
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