Guanahanolide A

Russell Kerr and co-workers from the University of Prince Edward Island in Canada reported on the isolation of guanahanolide A with moderate cytotoxicity against cancer cells.

 

OL paper

Talaromyolides E-K

Bin Wu and co-workers at Zhejiang University have reported on the isolation of talaromyolides E-K with antiviral activity towards the pseudorabies virus.

 

Tetrahedron paper

Anditomin biosynthesis

Ikuro Abe and co-workers from the University of Tokyo have reported in JACS on a biosynthetic study of anditomin.

JACS paper

Multi-component approach to guajadial B

Looking at this molecule, one would never think that you can mix three things, a penta-substituted benzene ring, benzaldehyde and humulene, and obtain the final compound, guajadial! Ji-Kai Liu and co-workers at the Kunming Institute of Botany did such a thing!

OL paper

Aureol from sclareolide

Jonathan George and co-workers at the University of Adeleide in Australia have reported in Organic Letters on the synthesis of aureol from sclareolide.

OL paper

Austinol and dehydroaustinol

Clay Wang and co-workers at USC have reported in JACS on the biosynthesis determination of two meroterpenoids.

JACS paper

Scabellones

Brent Copp and co-workers from the University of Auckland have reported in the Journal of Organic Chemistry on the isolation of some bioactive compounds dubbed scabellones.

JOC paper

Biyoulactones A-C

Jun’ichi Kobayashi and co-workers from Hokkaido University have reported in Organic Letters on the isolation of pentacyclic meroterpenoids dubbed biyoulactones A-C.

OL paper

Cytosporolides

Yongsheng Che and co-workers at the Chinese Academy of Sciences have published in Organic Letters on the isolation of meroterpenoids.

OL paper

Liphagal Synthesis

We’ve previously seen a synthesis of liphagal but here’s another approach to synthesize the seven membered ring from a similar diol precursor – however, the one found here reported by Enrique Alvarez-Manzaneda and co-workers at the Universidad de Granada combines a benzyl deprotection and cationic ring expansion in one step.

OL paper