Yi-Xia Jia and co-workers from Zhejiang University have reported in JACS on an intramolecular desymmetrization by a Heck reaction.
Posted by naturalproductman on May 21, 2013
Jianwei Sun and co-workers from the Hong Kong University of Science and Technology have reported in ACIE on a desymmetrization of oxetanes using a phosphoric acid catalyst.
Posted by naturalproductman on May 23, 2011
Keiji Maruoka and co-workers from Kyoto University have reported in JACS on a desymmetrization process of a cyclohexanone using an alphadiazoacetate reagent to afford seven membered rings.
Posted by naturalproductman on August 12, 2010
One of the classical ways to study a reaction’s mechanism is to use the linear free energy relationship analysis – Scott Miller (Yale) and Matthew Sigman (Utah) have published in Organic Letters on their LFER analysis of a desymmetrization reaction using a diarylmethane-bisphenol substrate with the peptide catalyst that Miller has been using to desymmetrize meso starting materials. The reaction in this paper is to selectively acetylate one of the phenols over the other to yield chiral products – the third substituent on the methane was varied with sterically different groups.