Archive for the ‘Desymmetrization’ Category
Posted by naturalproductman on April 19, 2016
Yi-Xia Jia and co-workers from Zhejiang University have reported in JACS on an intramolecular desymmetrization by a Heck reaction.
JACS paper
Posted in Desymmetrization, Heck, Methodology, Mizoroki-Heck, Organocatalytic, Palladium, Transition Metal | Leave a Comment »
Posted by naturalproductman on January 17, 2015
Aaron Sadow and co-workers at Iowa State have reported in JACS on a desymmetrization hydroamination reaction using a zirconium catalyst and the result is different depending on whether the reaction is dilute or concentrated.
JACS paper
Posted in Desymmetrization, Methodology, Transition Metal, Zirconium | Leave a Comment »
Posted by naturalproductman on May 21, 2013
Jianwei Sun and co-workers from the Hong Kong University of Science and Technology have reported in ACIE on a desymmetrization of oxetanes using a phosphoric acid catalyst.
ACIE paper
Posted in Asymmetric, Desymmetrization, Methodology | Leave a Comment »
Posted by naturalproductman on June 13, 2012
Koichi Mikami and co-workers from Tokyo Institute of Technology have reported in JACS on a desymmetrization approach to access madindoline B.
JACS paper
Posted in Alkaloids, Asymmetric, Cascade Reactions, Copper, Desymmetrization, Methodology, Transition Metal | Leave a Comment »
Posted by naturalproductman on November 12, 2011
Pauline Chiu and co-workers from the University of Hong Kong have published in Tetrahedron Letters on a desymmetrization of a meso compound to form a five membered ring with modest ee (50% ee).
TL paper
Posted in C2-Symmetric, Carbene, Copper, Desymmetrization, Methodology, Transition Metal | Leave a Comment »
Posted by naturalproductman on August 24, 2011
My first look at the authors on this paper made me think: “Whoa Woodward’s back from the dead” but I realized the middle initial is different.
ACIEE paper
Posted in Alkaloids, Asymmetric, Desymmetrization, Methodology, Palladium, Transition Metal | 1 Comment »
Posted by naturalproductman on May 23, 2011
Keiji Maruoka and co-workers from Kyoto University have reported in JACS on a desymmetrization process of a cyclohexanone using an alphadiazoacetate reagent to afford seven membered rings.
JACS paper
Posted in Asymmetric, Carbene, Cascade Reactions, Desymmetrization, Methodology, Ring expansion, Ring Opening | Leave a Comment »
Posted by naturalproductman on August 12, 2010
One of the classical ways to study a reaction’s mechanism is to use the linear free energy relationship analysis – Scott Miller (Yale) and Matthew Sigman (Utah) have published in Organic Letters on their LFER analysis of a desymmetrization reaction using a diarylmethane-bisphenol substrate with the peptide catalyst that Miller has been using to desymmetrize meso starting materials. The reaction in this paper is to selectively acetylate one of the phenols over the other to yield chiral products – the third substituent on the methane was varied with sterically different groups.
OL paper
Posted in Asymmetric, Desymmetrization, Mechanistic, Methodology, Organocatalytic | Leave a Comment »