The nobel prize in medicine announcement was made and the trio of winners (Satoshi Omura, William Campbell, and Youyou Tu) had done natural product isolation work – one was Youyou Tu, the Chinese woman who discovered artemisinin (half of the prize)! An exciting win for natural product research!
Archive for the ‘Unnatural Products’ Category
Posted by naturalproductman on October 5, 2015
Posted by naturalproductman on June 7, 2015
Hans-Günther Schmalz and co-workers from Universität zu Köln have reported in ACIE on some small molecules that release carbon monoxide upon reacting with protease.
Posted by naturalproductman on November 29, 2014
Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.
Posted by naturalproductman on November 27, 2014
Ehud Landau and co-workers at the University of Zurich have reported in ACIE on the use of a cyclopropane-containing lipid to crystallize membrane proteins.
Posted by naturalproductman on October 4, 2014
Michael Spiteller and co-workers at TU Dortmund have reported in ACIE that tramadol is actually not a natural product. This study just points out the importance of uncovering the biosynthesis pathways of natural products.
Posted by naturalproductman on August 20, 2014
Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.
Posted by naturalproductman on June 7, 2014
Gisbert Schneider and co-workers from ETH Zurich have reported in ACIE on some anti-malarial pyrrolopyrazines.
Posted by naturalproductman on September 5, 2013
Michelle Chang and co-workers at Berkeley have reported in Science on a way to access fluorinated natural products using fluoroacetate as the building block.
Posted by naturalproductman on October 25, 2012
Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.