Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘Unnatural Products’ Category

Vancomycin derivative

Posted by naturalproductman on May 29, 2016

Here’s a report on a vancomycin derivative with a pyrophosphate binding group reported by Jayanta Haldar and co-workers at Jawaharlal Nehru Centre for Advanced Scientific Research.

 

ACIE paper

Posted in Antibiotics, Peptides, Unnatural Products | Leave a Comment »

Why natural products are important (an update)

Posted by naturalproductman on February 9, 2016

Remember that natural products review by David Newman and Gordon Cragg from the NIH?

 

Here is an updated (2016) one covering new chemical entities, antibacterial, antifungal, antiviral, anticancer, antiparasitic, and anticancer from 1981 to 2014:

 

JNP paper

Posted in Cancer, Random, Unnatural Products | Leave a Comment »

Nuphar alkaloid chemical biology

Posted by naturalproductman on February 8, 2016

Jimmy Wu and co-workers reported in ACIE on the formal synthesis of nuphar alkaloids and their apoptotic activity. Did you know that the second “p” in “apoptosis” is silent and it is pronounced “apa-tosis”? The Greek word “apoptosis” means “falling off” or “dropping off” of flower petals or tree leaves.

 

ACIE paper

Posted in Chemical Biology, Random, Unnatural Products | Leave a Comment »

Using carbon dating to show that tramadol is NOT a natural product afterall

Posted by naturalproductman on October 21, 2015

Remember that debate whether tramadol was really a natural product or not? Michael Spiteller and co-workers at TU Dortmund used accelerator mass spectrometry to analyze the isotopes of carbon found in tramadol found in the soil to show that tramadol is NOT a natural product. This is all based on the fact that natural organic compounds that are biosynthesized in living organisms contain amounts of 14C-radioisotope close to that of the environment.
tramadol
ACIE paper

Posted in Mass Spectrometry, Unnatural Products | Leave a Comment »

Another validation for natural product research

Posted by naturalproductman on October 5, 2015

The nobel prize in medicine announcement was made and the trio of winners (Satoshi Omura (avermectin), William Campbell (ivermectin), and Youyou Tu) had done natural product isolation work – one was Youyou Tu, the Chinese woman who discovered artemisinin (half of the prize)! An exciting win for natural product research!

Posted in Diseases, Malaria, Random, Unnatural Products | Leave a Comment »

CO-Releasing molecules (CORMs)

Posted by naturalproductman on June 7, 2015

Hans-Günther Schmalz and co-workers from Universität zu Köln have reported in ACIE on some small molecules that release carbon monoxide upon reacting with protease.

CO

ACIE paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Combining chemical and enzymatic synthesis

Posted by naturalproductman on November 29, 2014

Kevin Reynolds and co-workers from Portland State University have reported in JOC on the synthesis of premarineosin analogs using a chemo-enzymatic approach.

marineosin

JOC paper

Posted in Alkaloids, Chemical Biology, Enzymatic, Methodology, Total Synthesis, Unnatural Products | 1 Comment »

Monodihydrosterculin

Posted by naturalproductman on November 27, 2014

Ehud Landau and co-workers at the University of Zurich have reported in ACIE on the use of a cyclopropane-containing lipid to crystallize membrane proteins.
MDS

ACIE paper

Posted in Chemical Biology, Lipids, New Setups, Unnatural Products | Leave a Comment »

On tramadol

Posted by naturalproductman on October 4, 2014

Michael Spiteller and co-workers at TU Dortmund have reported in ACIE that tramadol is actually not a natural product. This study just points out the importance of uncovering the biosynthesis pathways of natural products.

tramadol

 

ACIE paper

 

Old post on tramadol

Posted in Unnatural Products | Leave a Comment »

Cholesterol analog to probe SHH protein

Posted by naturalproductman on August 20, 2014

Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.

cholesterol

Chemical Science paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

 
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