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Archive for the ‘Ambiguine’ Category

Ambiguine Isonitriles

Posted by naturalproductman on June 24, 2009

A group of ambiguine isonitriles were isolated in the lab of Jimmy Orjala at the University of Illinois in Chicago from the cyanobacterium Fischerella ambigua.  Ambiguine A isonitrile had the most potent activity towards B. anthracis with a MIC of 1.0 micromolar.  These molecules are structurally and biogenetically related to hapalindoles.

ambiguine isonitriles

JNP paper

Posted in Alkaloids, Ambiguine, Seven-Membered Rings | 1 Comment »