Naturalproductman’s Blog

Hey, is that a natural product?!

Archive for the ‘New Techniques’ Category

A natural product binding protein

Posted by naturalproductman on February 12, 2016

Using NMR, David Jakeman and co-workers at Dalhousie University reported in JACS on a natural product binding protein, JadX.

 

JACS paper

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Posted in New Techniques, NMR, Polyketides | Leave a Comment »

Biochemometric analysis ~ natural products (altersetin)

Posted by naturalproductman on February 9, 2016

Nadja Cech and co-workers at UNC Greensboro have reported in the Journal of Natural Products on the isolation of altersetin, an antibacterial alkaloid.

 

JNP paper

Posted in Alkaloids, Antibiotics, New Techniques | Leave a Comment »

Crystalline Sponge Method to Determine Absolute Configuration

Posted by naturalproductman on January 19, 2016

X-ray crystallography is usually a good method to determine the relative configuration of natural products (i.e. diastereomers) containing more than one stereocenter. However, the method of determining the absolute configuration of natural products is very difficult by just using X-ray crystallography. Here’s a paper from the labs of Sylvia Urban (RMIT University) and Makoto Fujita (University of Tokyo)  that reports on the use of the crystalline sponge method to determine the absolute stereochemistry of elatenyne.

 

ACIE paper 

 

Other ways to determine absolute configuration by X-ray crystallography include derivatization with a chiral reagent then crystallizing, using the effects of anomalous dispersion (Friedif values).

Posted in Asymmetric, New Techniques, Tetrahydrofuran | Leave a Comment »

Mollenynes B-E

Posted by naturalproductman on September 25, 2015

Tadeusz Molinski and co-workers have reported in JACS on the isolation and characterization of mollenynes B-E.
mollenynes
JACS paper

Posted in Alkynes, Computational, DFT, Halogenated, New Techniques, NMR, Peptides, Polyenes, Stereochemistry | Leave a Comment »