Cholesterol analog to probe SHH protein

Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.

Chemical Science paper

Anti-malarial pyrrolopyrazines

Gisbert Schneider and co-workers from ETH Zurich have reported in ACIE on some anti-malarial pyrrolopyrazines.

ACIE paper

Fluorinated compounds, biosynthetically

Michelle Chang and co-workers at Berkeley have reported in Science on a way to access fluorinated natural products using fluoroacetate as the building block.

 

Science paper

Tubulexin chemical biology

Herbert Waldmann and co-workers at Max Planck have reported in ACIE on the chemical biology of tubulexins.

ACIE paper

Gambierol analogs

Luis Botana and co-workers from Universidad de Santiago de Compostela, Lugo, Spain have reported in JACS on the synthesis of gambierol analogs.

JACS paper

Vinblastine analogs

Dale Boger and colleagues have reported in Organic Letters on the functionalization of alkenes using iron. When I first saw vinblastine I thought of Dale Boger because he does so much work on this compound and it looks like I was thinking the right person.

OL paper

Vancomycin analogs

Whenever I see vancomycin’s structure I always think of Dale Boger. This time he and co-workers have published in JACS on the synthesis of some vancomycin analogs.

JACS paper

Fluorinated calystegnine B2

Jonathan Percy and co-workers at the University of Strathclyde in the UK have reported in JOC on the synthesis of a fluorinated calystegnine B2 analog.

JOC paper

Chemical synthesis with biosynthesis

Andreas Kirschning and co-workers at have reported in ACIEE on a combined biosynthesis/chemical synthesis approach to synthesize new ansamitocin analogs.

ACIEE paper

Cribrostatin analogs

Stephen Martin and colleague have reported in Tetrahedron on their cribrostatin analog synthesis via radical cyclization cascade to access the aromatic ring.  We’ve seen this chemistry before when they reported their synthesis in ACIEE.

Tetrahedron paper