Naturalproductman’s Blog

Hey, is that a natural product?!

Multi-component coupling with cobalt

Posted by naturalproductman on November 28, 2014

Xiaobing Wan and co-workers from Soochow University have reported in ACIE on a multi-component coupling approach to access β-Ester-γ-amino ketones.

tbhp

ACIE paper

Posted in Cascade Reactions, Cobalt, Methodology, Multi-Component Coupling, Transition Metal | Leave a Comment »

N-Tosyl hydrazones to alkynes with copper

Posted by naturalproductman on November 28, 2014

Huanfeng Jiang and co-workers from South China University of Technology have reported in ACIE on a copper catalyzed conversion of N-tosyl hydrazones to alkynes. The problem is I don’t know how regioselective this is.

copper

ACIE paper

Posted in Copper, Methodology, Transition Metal | Leave a Comment »

Lipiarmycin synthesis

Posted by naturalproductman on November 28, 2014

Jieping Zhu and co-workers at CNRS have reported in ACIE on the synthesis of lipiarmycin.

polyketide

ACIE paper

Posted in Glycosides, Methodology, Polyketides, Total Synthesis | Leave a Comment »

Plantazolicin A synthesis

Posted by naturalproductman on November 28, 2014

Steven Ley and co-workers at the University of Cambridge have reported in ACIE on the syntheses of plantazolicins A and B.

thiazole

ACIE paper

Posted in Methodology, Oxazoles, Thiazoles, Total Synthesis | Leave a Comment »

Mogolides A and B syntheses

Posted by naturalproductman on November 28, 2014

Yefeng Tang and co-workers from Tsinghua University have reported in ACIE on the synthesis mogolides A and B.

biomimetic

ACIE paper

Posted in Diels-Alder, Dimer, Named Reactions, Polyketides, Total Synthesis | Leave a Comment »

Fidaxomicin synthesis

Posted by naturalproductman on November 28, 2014

Karl Gademann and co-workers at the University of Basel have reported in ACIE on the synthesis of
fidaxomicin
ACIE paper

Posted in Methodology, Named Reactions, Polyketides, Total Synthesis, Yamaguchi macrolactonization | Leave a Comment »

Apoptolidins localize in mitochondria

Posted by naturalproductman on November 28, 2014

Gary Sulikowski and co-workers at Vanderbilt University have reported in ACIE on the use of some fluorescent probe versions of apoptolidin natural products and determined that the natural product localizes in the mitochondria of cancer cells.

mitochondria

ACIE paper

Posted in Cancer, Chemical Biology, lung, Polyketides | Leave a Comment »

Monodihydrosterculin

Posted by naturalproductman on November 27, 2014

Ehud Landau and co-workers at the University of Zurich have reported in ACIE on the use of a cyclopropane-containing lipid to crystallize membrane proteins.
MDS

ACIE paper

Posted in Chemical Biology, Lipids, New Setups, Unnatural Products | Leave a Comment »

Alsmaphorazine D synthesis

Posted by naturalproductman on November 27, 2014

Hanfeng Ding and co-workers have reported in ACIE on the synthesis of alsmaphorazine D.
indole

ACIE paper

Posted in Alkaloids, Indoles, Total Synthesis | Leave a Comment »

Cucurbitacins make wild cucumbers bitter

Posted by naturalproductman on November 27, 2014

Yi Shang and co-workers at the Chinese Academy of Agricultural Sciences have reported in Science on the genes that make cucmbers bitter and the selection process that made domestic cucumbers not bitter – it had to do with the transcription factor called Bitter fruit.

Science paper

Posted in Food, Steroids | Leave a Comment »

 
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