Naturalproductman’s Blog

Hey, is that a natural product?!

CO2 as a protecting group?

Posted by naturalproductman on August 20, 2014

Arjan Kleij and co-workers from ICIQ in Spain have reported in ACIE on the use of carbon dioxide as a protecting group for cis-diols arising from epoxides using an iron or aluminum aminotriphenolate complex to make the carbonate from the epoxide.

carbon dioxide

ACIE paper

Posted in Methodology, New Types, Protecting Groups | 2 Comments »

Cholesterol analog to probe SHH protein

Posted by naturalproductman on August 20, 2014

Edward Tate and co-workers from Imperial College in London have reported in Chemical Science on a cholesterol analog that allowed them to probe the sonic hedgehog protein, a peptide that undergoes post-translational modification with cholesterol.

cholesterol

Chemical Science paper

Posted in Chemical Biology, Unnatural Products | Leave a Comment »

Sinulariaoid A

Posted by naturalproductman on August 20, 2014

Cui-Xian Zhang and co-workers from Guangzhou University have reported in Tetrahedron on a poly-sulfur lactone compound.

sulfur

Tetrahedron paper

Posted in Apoptosis, Cancer, Lactones, Polythio Compounds | Leave a Comment »

Cyclobutenone ring expansion

Posted by naturalproductman on August 20, 2014

Guangbin Dong and colleague at UT Austin have reported in ACIE on the synthesis of cycloinumakiol through a rhodium catalyzed cascade reaction that forms the tetracyclic ring structure of the compound.

C-C

ACIE paper

Posted in Methodology, One pot, Rhodium, Ring expansion, Ring forming, Ring Opening, Total Synthesis, Transition Metal | Leave a Comment »

Z-selective olefin metathesis

Posted by naturalproductman on August 20, 2014

Robert Grubbs and co-workers have reported in JACS on factors that influence Z-selective olefin metathesis.

Z-selective

JACS paper

Posted in Metathesis, Methodology, Ring forming, Ruthenium, Transition Metal | Leave a Comment »

Gymnothelignan N synthesis

Posted by naturalproductman on August 18, 2014

Xuegong She and co-workers from Lanzhou University have reported in Organic Letters on the synthesis of

Friedel-Crafts

OL paper

Posted in Friedel-Crafts, Named Reactions, Spirocycles, Spirocyclic centers, Total Synthesis | Leave a Comment »

Belizentrin synthesis

Posted by naturalproductman on August 18, 2014

Hernandez Daranas and co-workrs from the University of La Laguna in Spain have reported in Organic Letters on the isolation of belizentrin.

belizentrin

OL paper

Posted in Macrocycles | Leave a Comment »

(+)-Procyanidin A2 and (+)-Cinnamtannin B1 syntheses

Posted by naturalproductman on August 18, 2014

Keisuke Suzuki and co-workers from Tokyo Institute of Technology have reported in ACIE on the synthesis of (+)-procyanidin A2 and (+)-cinnamtannin B1.

aromatic

ACIE paper

Posted in Aromatic, Total Synthesis | Leave a Comment »

Merochlorins A and B syntheses, enzymatically

Posted by naturalproductman on August 18, 2014

Bradley Moore and Phil Baran’s groups teamed up to synthesize merochlorin A and B.

Merochlorin

ACIE paper

Posted in Biosynthesis, Chemical Biology, Enzymatic, Polyketides, Total Synthesis | Leave a Comment »

Delta12-prostaglandin J3 synthesis

Posted by naturalproductman on August 18, 2014

Nicolaou and co-workers have reported in ACIE on the synthesis of delta12-prostaglandin J3.

prostaglandin J3

ACIE paper

Posted in Aldol, Cancer, leukemia, Methodology, Polyenes, Prostaglandins, Total Synthesis | Leave a Comment »

 
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