Naturalproductman’s Blog

Hey, is that a natural product?!

Lomaiviticins and DNA damage

Posted by naturalproductman on July 16, 2014

Seth Herzon and co-workers have reported in ACIE on the DNA damage activity of lomaiviticins.

lomaiviticins

ACIE paper

Posted in Aromatic, Chemical Biology | Leave a Comment »

Rhodium cascade

Posted by naturalproductman on July 16, 2014

Richmond Sarpong and co-workers have reported in ACIE on a rhodium catalyzed cascade reaction involving an aza-Cope rearrangement.

Cope

ACIE paper

Posted in Aza-Cope rearrangement, Cascade Reactions, Methodology, Named Reactions, Rhodium, Transition Metal | Leave a Comment »

Claisen-Diels-Alder cascade to spirooliganones A and B

Posted by naturalproductman on July 16, 2014

Rongbiao Tong and co-workers from the Hong Kong University of Science and Technology have reported in Org Lett on a slick reaction to form spirooliganones.

 
spirooliganones

OL paper

Posted in Cascade Reactions, Claisen rearrangement, Diels-Alder, Methodology, Named Reactions, Total Synthesis | Leave a Comment »

How long does it take to publish in ACIE?

Posted by naturalproductman on July 16, 2014

Ever wonder how long it takes to publish in ACIE?

 

Here’s an interesting article in Chimia that explains the process. Conclusion:  it takes about 13 days on average for a referee to review a submitted manuscript.

 

Chimia paper

Posted in Random | 1 Comment »

Indole alkaloid synthesis

Posted by naturalproductman on July 15, 2014

Corey Stephenson and colleague at the University of Michigan have reported in JACS on the synthesis of pseudotabersonine. A mental roadblock for me was when I was looking at the paper, I was trying to find the structure of catalyst 5, which was the iridium catalyst used for a ring opening reaction, but just found the number 5 in the scheme. Within the text of the paper however it says Ir(dF(CF3)ppy)2(dtbbpy)PF6, which was cited with a Sigma Aldrich catalog number.

 

photoredox

JACS paper

Posted in Alkaloids, Indoles, Iridium, Light Mediated, Methodology, Transition Metal | Leave a Comment »

1-Alaninechlamydocin

Posted by naturalproductman on July 15, 2014

Robert Cichewicz and co-workers from the University of Oklahoma have reported in the Journal of Natural Products on the isolation of a tetrapeptide with HDAC inhibitory activity. This compound was isolated from a fungus in Lake Superior.

peptide

JNP paper

Posted in Cancer, Histone deacetylase, Peptides, Protein Targets | Leave a Comment »

Cyanogramide

Posted by naturalproductman on July 15, 2014

Weiming Zhu and co-workers at Ocean University of China have reported in Organic Letters on the isolation of cyanogramide.

cyanogramide

OL paper

Posted in Alkaloids, Cancer, Spirocycles | Leave a Comment »

Acanthomanzamines

Posted by naturalproductman on July 15, 2014

Sachiko Tsukamoto and co-workers from Kumamoto University have reported in Organic Letters on the isolation of acanthomanzamines.

acanthomanzamine

OL paper

Posted in Alkaloids | Leave a Comment »

Agelamadins

Posted by naturalproductman on July 15, 2014

More oroidin dimers were isolated – I was reminded of palau’amine.

agelamadins

OL paper

Posted in Alkaloids, Antibiotics | Leave a Comment »

Crinipellin A synthesis

Posted by naturalproductman on July 12, 2014

Hee-Yoon Lee and co-workers at KAIST have reported in JACS on the synthesis of crinipellin A.

synthesis

JACS paper

Posted in Allenes, Methodology, Total Synthesis | Leave a Comment »

 
Follow

Get every new post delivered to your Inbox.

Join 68 other followers