Naturalproductman’s Blog

Hey, is that a natural product?!

Peganumine A

Posted by naturalproductman on July 27, 2014

Hui-Ming Hua and co-workers from Shenyang Pharmaceutical University have reported in Organic Letters on the isolation of peganumine A, which had an IC50 value of 5.8 μM against HL-60 cells.

peganumine A

OL paper

Posted in Alkaloids, Cancer | Leave a Comment »

Rearrange to more complexity

Posted by naturalproductman on July 27, 2014

Paul Hergenrother and co-workers from UIUC have reported in ACIE on an interesting rearrangement to form fenestrane ring systems.

cyclopropane

ACIE paper

Posted in Antibiotics, Cascade Reactions, Mechanistic, Methodology | Leave a Comment »

Electrocyclic ring opening to ketonitrones

Posted by naturalproductman on July 27, 2014

Masahiro Terada and co-workers from Tohoku University have reported in Organic Letters on a copper-catalyzed rearrangement to form alpha,beta-unsaturated ketonitrones.

nitrone

OL paper

Posted in Cascade Reactions, Copper, Electrocyclization, Mechanistic, Methodology, Pericyclic reactions, Transition Metal | Leave a Comment »

Aryl halide couplings with Sp3-carbons

Posted by naturalproductman on July 27, 2014

Gary Molander and colleagues reported in Science on a photoredox nickel dual catalysis for a cross coupling reaction between an sp3-hybridized organoboron and an aryl halide.

Science paper (Molander)

In the same issue, David Macmillan and co-workers have reported on a photoredox reaction involving a nickel catalyzed coupling between an sp3-alpha-carboxyl and an aryl halide.

Science paper (Macmillan)

 

Posted in Cascade Reactions, cross coupling, Light Mediated, Methodology, Nickel, Transition Metal | Leave a Comment »

C-O bond cleavage with Ir

Posted by naturalproductman on July 27, 2014

Alan Goldman and co-workers from Rutgers have reported in ACIE on an iridium pincer complex catalyzed C-O bond cleavage.

C-O

ACIE paper

Posted in Catalytic, Iridium, Methodology, Transition Metal | Leave a Comment »

Bislactone desymmetrization

Posted by naturalproductman on July 27, 2014

Jieping Zhu and co-workers have reported in ACIE on the synthesis of rhazinilam and leucomidine B.

desymmetrize

ACIE paper

Posted in Alkaloids, Asymmetric, C2-Symmetric, Cascade Reactions, Methodology, Organocatalytic | Leave a Comment »

Aluminum porphyrin

Posted by naturalproductman on July 27, 2014

George O’Doherty and co-workers from Northeastern University have reported in JACS on an aluminum catalyzed beta-lactone synthesis from epoxides.

aluminum

JACS paper

Posted in Cascade Reactions, Lactones, Methodology, Total Synthesis | Leave a Comment »

Carboboration, organocatalytically

Posted by naturalproductman on July 27, 2014

Masaya Sawamura and co-workers at Hokkaido University have reported in JACS on a carboboration of alkynoates.

carboboration

JACS paper

Posted in Conjugate Additions, Methodology, Organocatalytic | Leave a Comment »

Scripps president leaving?

Posted by naturalproductman on July 23, 2014

I wonder where the Scripps president is going?

Posted in Uncategorized | Leave a Comment »

Lomaiviticins and DNA damage

Posted by naturalproductman on July 16, 2014

Seth Herzon and co-workers have reported in ACIE on the DNA damage activity of lomaiviticins.

lomaiviticins

ACIE paper

Posted in Aromatic, Chemical Biology | Leave a Comment »

 
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