Naturalproductman’s Blog

Hey, is that a natural product?!

Forazoline A

Posted by naturalproductman on September 10, 2014

I thought I was going to have some down time before I posted again, but I ran into this interesting isolation paper of forazoline A that is worth a gander from Tim Bugni’s lab in the University of Wisconsin. They used a 15N-13C HMQC technique to determine which carbon was bonded to which nitrogen, which is apparently the first time this technique was used for a natural product. Looks like a pretty large natural product (m/z 901.4205). They have an interesting looking 13C NMR spectrum of the natural product (13C-labeled) that have splitting patterns on basically all of the carbons of the natural product (and thus looks like a proton NMR).

ACIE paper

Posted in Antifungal, New Setups, New Types, NMR, Polyketides, Polythio Compounds, Thiazoles | Leave a Comment »

Amphirionin-4

Posted by naturalproductman on September 8, 2014

Masashi Tsuda and co-workers from Kochi University have reported in Organic Letters on the isolation of amphirionin-4.

amphirionin-4

OL paper

Posted in Polyenes | Leave a Comment »

Hyperuralones A and B

Posted by naturalproductman on September 8, 2014

Gang Xu and co-workers from the Chinese Academy of Sciences have reported in Organic Letters on the isolation of hyperuralones A and B, which had low micro molar IC50 activity against cancer cells.

cancer

OL paper

Posted in Cancer, Diels-Alder, Isoprenoids, Named Reactions | Leave a Comment »

Allenyl gold complexes

Posted by naturalproductman on September 8, 2014

Concepcion Gimeno and co-workers from ISQCH in Spain have reported in JACS on an allenyl gold complex. I wonder how they would react with electrophiles.

allenyl gold

JACS paper

Posted in Allenes, Gold, Methodology, Transition Metal | Leave a Comment »

Asymmetric metathesis

Posted by naturalproductman on September 8, 2014

Grubbs and colleagues have reported in JACS on their studies with asymmetric ring closing metathesis.

asymmetric

JACS paper

Posted in Asymmetric, Cascade Reactions, Metathesis, Methodology, Ring Opening | 1 Comment »

Towards plumarellide

Posted by naturalproductman on August 31, 2014

Gerald Pattenden and co-workers from the University of Nottingham in the UK have reported in Tetrahedron on a [4+2] approach to plumarellide.

4+2
Tetrahedron paper

Posted in Cascade Reactions, Methodology | 2 Comments »

Oxepanes via Ferrier

Posted by naturalproductman on August 31, 2014

Srinivasan Chandrasekaran and co-workers at the Indian Institute of Science have reported in Tetrahedron on a Ferrier rearrangement to form oxepanes.

 

Ferrier

Tetrahedron paper

Posted in Cascade Reactions, Ferrier, Methodology, Named Reactions, Ring expansion, Ring Opening | Leave a Comment »

Organocatalytic epoxidation

Posted by naturalproductman on August 31, 2014

Philip Bulman Page and co-workers at the University of East Anglia have reported in Tetrahedron on an iminium catalyzed epoxidation.
epoxidation

Tetrahedron paper

Posted in Asymmetric, Methodology, Organocatalytic | Leave a Comment »

Aspeverin synthesis

Posted by naturalproductman on August 30, 2014

Adam Levinson at Sloan Kettering has reported in Organic Letters on the synthesis of aspeverin. Interestingly, Danishefsky was acknowledged for the mentorship but not included in the authors list. I wonder if this is a new kind of way to publish.

aspeverin

OL paper

Posted in Alkaloids, Hypervalent Iodine, Methodology, Total Synthesis | 3 Comments »

ZMapp vs. ebola

Posted by naturalproductman on August 30, 2014

Gary Kopinger and co-workers from the University of Manitoba have reported in Nature on ZMapp’s reversion of the ebola virus.
Nature paper

Posted in Anti-viral, Diseases | Leave a Comment »

 
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