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Cyclopropanation ring expansion

Posted by naturalproductman on April 8, 2016

Martin Trmblay and co-workers from Infinity Pharmaceuticals have reported in Organic Process Research & Development on a scalable 6 to 7 membered ring expansion towards a hedgehog antagonist. When I looked at the structure it reminded me of cyclopamine.

ORPD paper

This entry was posted on April 8, 2016 at 6:31 am and is filed under Cascade Reactions, Methodology, Ring expansion, Zinc. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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Cyclopropanation ring expansion

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