Naturalproductman’s Blog

Hey, is that a natural product?!

Cyclopropanation ring expansion

Posted by naturalproductman on April 8, 2016

Martin Trmblay and co-workers from Infinity Pharmaceuticals have reported in Organic Process Research & Development on a scalable 6 to 7 membered ring expansion towards a hedgehog antagonist. When I looked at the structure it reminded me of cyclopamine.

 

ORPD paper

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